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GI - 2 > Hepatitis B Medications > Flashcards

Hepatitis B Medications Flashcards

1
Q

Is there treatment for an ACUTE HBV infection?

A

NO - resolves on its own

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2
Q

What are 3 goals for treatment of CHRONIC HBV infection?

A
  1. Decrease HBV DNA
  2. Convert HbeAg from (+) to (-)
  3. Decrease ALT/AST
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3
Q

If the goals for treatment of Chronic HBV infection are achieved, what will that do?

A

Lower the patient’s risk for cirrhosis, hepatocellular carcinoma and liver transplant

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4
Q

Is it possible to cure HBV?

A

RARE - do not usually eradicate the virus

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5
Q

Why is it rare to cure HBV?

A

The covalently closed circular viral DNA always exists in cell and is a reservoir that gives HBV the ability to reactivate

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6
Q

Relapse is more common in those co-infected with?

A

HDV

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7
Q

What are 6 drugs that can treat Chronic HBV?

A 
Entecavir
Tenofovir Disoproxil
Adefovir
Lamivudine
Telbivudine
PEG Interferon Alfa-2a
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8
Q

What are 6 drugs that can treat Chronic HBV?

A 
Entecavir
Tenofovir Disoproxil
Adefovir
Lamivudine
Telbivudine
PEG Interferon Alfa-2a
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9
Q

What are 6 drugs that can treat Chronic HBV?

A 
Entecavir
Tenofovir Disoproxil
Adefovir
Lamivudine
Telbivudine
PEG Interferon Alfa-2a
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10
Q

Nucleoside Analogue Reverse Transcriptase

A

Entecavir

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11
Q

Indications for Entecavir?

A

** > 2 years old:
Chronic HBV infection with active viral replication
- with elevated AST/ALT OR
- histologically active disease

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12
Q

Adverse effects of Entecavir?

A

Headache
Fatigue
Dizziness
Nausea

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13
Q

Nucleotide Analog HIV-1 and HBV Reverse Transcriptase (-)

A

Tenofovir Disoproxil

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14
Q

Indications for Tenofovir Disoproxil?

A

** > 12 years old:
Chronic HBV infection
HIV-1 infection

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15
Q

Contraindications and adverse effects for Tenofovir Disoproxil?

A

Do not take if new onset or worsening renal impairment

= NEPHROTOXIC, nausea

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16
Q

Nucleotide Analog

A

Adefovir

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17
Q

Indications for Adefovir?

A

** > 12 years old:

Chronic HBV infection

18
Q

Contraindications of Adefovir?

A
  • If patients have hypersensitivity reaction

- May cause NEPHROTOXICITY or worsen hepatitis

19
Q

Due to Adefovir’s ability to be nephrotoxic, what should you monitor during therapy?

A

Renal function

20
Q

Adverse effects of Adefovir?

A

NEPHROTOXICITY
asthenia (weakness)
Increased creatinine

21
Q

Adefovir has drug interactions. What drugs will it react with and what happens?

A

Drugs that decrease renal function

= increases serum concentrations of Adefovir or other agent

22
Q

Which drugs are potentially nephrotoxic?

A

Tenofovir Disoproxil

Adefovir

23
Q

Nucleoside Analogue Reverse Transcriptase (-)’s?

A

Lamivudine

Telbivudine

24
Q

Nucleoside Analogue Reverse Transcriptase (-)’s?

A

Lamivudine

Telbivudine

25
Q

Lamivudine can also treat?

A

HIV-1

26
Q

What are the contraindications for Lamivudine?

A
  • patients with hypersensitivity to iamivudine
  • Pancreatitis
  • In pts with HIV-1 and HBV using ART that includes iamivudine = iamivudine resistant HBV
27
Q

Adverse effects of Lamivudine?

A

Headache, nausea, fatigue, cough, diarrrhea

28
Q

Indications for Telbivudine?

A

Chronic HBV infection with viral replication and

  • elevated AST/ALT OR
  • histologically active disease
29
Q

Telbivudine + PEG Interferon Alfa-2a may cause?

A

Peripheral neuropathy

30
Q

Telbivudine + PEG Interferon Alfa-2a may cause?

A

Peripheral neuropathy

31
Q

Adverse effects of Telbivudine?

A

Fatigue
Elevated Creatinine Kinase
Headache and cough

32
Q

PEG Interferon Alpha-2a can treat?

A

HBV and HCV chronic infections

33
Q

What are 3 contraindications for PEG Interferon Alfa-2a?

A
  1. Autoimmune hepatitis
  2. Hepatic decompensation
  3. neonates/infants
34
Q

Adverse effects of PEG Interferon Alfa-2a?

A

Flu like - fatigue, fever, muscle aches

35
Q

BB warning with PEG Interferon Alfa-2a?

A

Serious disorders and Ribavirin-associated effects

36
Q

Which drugs have similar BB warnings?

A

Entecavir
Tenofovir Disoproxil
Lamivudine
Telbivudine

37
Q

Which drugs have similar BB warnings?

A

Entecavir
Tenofovir Disoproxil
Lamivudine
Telbivudine

38
Q

What is the most common BB warnings?

A

Exacerbations of Hepatitis B
Lactic Acidosis
Hepatomegaly (+/- steatosis)

39
Q

What is the most common BB warnings?

A

Exacerbations of Hepatitis B
Lactic Acidosis
Hepatomegaly (+/- steatosis)

40
Q

Entecavir includes a BB warning with the usual items +?

A

Patient’s co-infected with HIV and HBV

GI - 2 (61 decks)

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