Acute Hepatitis Flashcards
Hepatitis
Liver inflammation
Most common etiologies for Acute Hepatitis?
Viral infection
Medications
Most common symptoms for Acute Hepatitis?
RUQ pain and hepatomegaly
N/V and Jaundice
Dark urine and Acholic stools
What is Acute Fulminant Liver Failure?
Massive hepatic necrosis with impaired consciousness within 8 weeks of onset of illness
What is the #1 cause of Acute Fulminant Liver Failure?
Acetaminophen overdose (APAP)
Sign/Symptoms of Acute Fulminant Liver Failure?
Rapidly SHRINKING liver
Confusion
Edema, Jaundice, pruritus, N/V
Symptoms of Acute Fulminant Liver Failure?
Rapidly SHRINKING liver
Confusion
Edema, Jaundice, pruritus, N/V
Describe the progression of the labs with Acute Fulminant Liver Failure as the liver fails
- ELEVATED AST/ALT
- ELEVATED bilirubin and prolonged PT/INR
- DECREASED AST/ALT
If Acetaminophen causes Acute Fulminant Liver Failure, above what number will the AST/ALT likely be?
> 5000
2 possible complications of Acute Fulminant Liver Failure?
- Cerebral/brainstem compression
- Sepsis and multi-organ failure
What is the treatment for Acetaminophen overdose?
N-Acetylcysteine
Liver transplant
What Nomogram should be used to find out Acetaminophen level?
Rumak - Matthew
Viral Hepatitis A
RNA virus
Fecal-oral spread
ACUTE
Viral Hepatitis A is more severe in ____
Adults
Is there a vaccine available for Hepatitis A?
YES
Labs with Hepatitis A?
Increased bilirubin and alkaline phosphatase
Increased AST/ALT
Treatment for Hepatitis A?
Supportive; self-limited
Viral Hepatitis B
DNA virus
Blood/sex/mother to baby spread
Usually ACUTE (some chronic)