Acute Hepatitis Flashcards

1
Q

Hepatitis

A

Liver inflammation

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2
Q

Most common etiologies for Acute Hepatitis?

A

Viral infection

Medications

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3
Q

Most common symptoms for Acute Hepatitis?

A

RUQ pain and hepatomegaly
N/V and Jaundice
Dark urine and Acholic stools

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4
Q

What is Acute Fulminant Liver Failure?

A

Massive hepatic necrosis with impaired consciousness within 8 weeks of onset of illness

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5
Q

What is the #1 cause of Acute Fulminant Liver Failure?

A

Acetaminophen overdose (APAP)

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6
Q

Sign/Symptoms of Acute Fulminant Liver Failure?

A

Rapidly SHRINKING liver
Confusion
Edema, Jaundice, pruritus, N/V

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7
Q

Symptoms of Acute Fulminant Liver Failure?

A

Rapidly SHRINKING liver
Confusion
Edema, Jaundice, pruritus, N/V

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8
Q

Describe the progression of the labs with Acute Fulminant Liver Failure as the liver fails

A
  • ELEVATED AST/ALT
  • ELEVATED bilirubin and prolonged PT/INR
  • DECREASED AST/ALT
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9
Q

If Acetaminophen causes Acute Fulminant Liver Failure, above what number will the AST/ALT likely be?

A

> 5000

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10
Q

2 possible complications of Acute Fulminant Liver Failure?

A
  • Cerebral/brainstem compression

- Sepsis and multi-organ failure

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11
Q

What is the treatment for Acetaminophen overdose?

A

N-Acetylcysteine

Liver transplant

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12
Q

What Nomogram should be used to find out Acetaminophen level?

A

Rumak - Matthew

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13
Q

Viral Hepatitis A

A

RNA virus
Fecal-oral spread
ACUTE

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14
Q

Viral Hepatitis A is more severe in ____

A

Adults

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15
Q

Is there a vaccine available for Hepatitis A?

A

YES

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16
Q

Labs with Hepatitis A?

A

Increased bilirubin and alkaline phosphatase

Increased AST/ALT

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17
Q

Treatment for Hepatitis A?

A

Supportive; self-limited

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18
Q

Viral Hepatitis B

A

DNA virus
Blood/sex/mother to baby spread
Usually ACUTE (some chronic)

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19
Q

What extra symptom may be seen with Hepatitis B?

A

Cutaneous Polyarteritis Nodosa

20
Q

Cutaneous Polyarteritis Nodosa is seen with?

A

Hepatitis B

21
Q

Labs with Hepatitis B?

A

Increased AST/ALT

Prolonged PT/INR – bleeding risk

22
Q

Hepatitis B has a window period. What is that?

A

Time between when the HBsAg has disappeared and the HBsAb has appeared
– weeks to months

23
Q

Hepatitis B has a window period. What is that?

A

Time between when the HBsAg has disappeared and the HBsAb has appeared
– weeks to months

24
Q

During the Window period with Hepatitis B, the patient is considered to have?

A

ACUTE hepatitis B!

25
Q

During the Window period with Hepatitis B, the patient has Acute Hepatitis B, what test will be (+)?

A

IgM

26
Q

Is there a vaccine available for Hepatitis B?

A

YES

27
Q

Viral Hepatitis D requires?

A

Hepatitis B infection!!

28
Q

What will be (+) with Hepatitis D?

A

HDV RNA PCR

29
Q

How do you protect against Hepatitis D?

A

Vaccinate against Hepatitis B

30
Q

Hepatitis D enhances severity of?

A

Hepatitis B infection

31
Q

Viral Hepatitis C

A

RNA
Blood/needle spread
CHRONIC

32
Q

Symptoms of Hepatitis C?

A

Mild and Asymptomatic

33
Q

Labs with Hepatitis C?

A

FLUCTUATING AST/ALT

34
Q

Fluctuating AST/ALT is seen with?

A

Hepatitis C

35
Q

(+) HCV RNA or Ab can diagnose Hepatitis C. If there are Anti-HCV in the serum but NO RNA, what does that mean?

A

Prior infection

36
Q

Is there a vaccine available for Hepatitis C?

A

NO

37
Q

Complications of Hepatitis C?

A

Cirrhosis
Mixed Cryoglobulinemia
Hepatocellular Carcinoma

38
Q

What is the recommended prevention for Hepatitis C?

A
  • Screen baby boomers and those over 18, along with blood products
  • Do not share toothbrush or razor if infected
39
Q

Viral Hepatitis E

A

RNA
Fecal-oral (swine) spread
ACUTE or CHRONIC if immunocompromised

40
Q

When will Viral Hepatitis E be Chronic?

A

In immunocompromised patients

41
Q

When will Hepatitis E progress from Chronic to Cirrhosis?

A

In transplant patients on Tacrolimus

42
Q

When can Fulminant Hepatitis E occur?

A

In pregnant patients

43
Q

Is there a vaccine available for Hepatitis E?

A

NO

44
Q

In what Hepatitis’s is there vaccines available?

A

A and B

45
Q

Symptoms of Acute Hepatitis?

A

RUQ pain, Hepatomegaly
Jaundice and N/V
Dark urine and Acholic stool