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GI - 2 > Agents for Diarrhea > Flashcards

Agents for Diarrhea Flashcards

1
Q

What is a Prostaglandin (-) that can be used to treat Diarrhea?

A

Bismuth

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2
Q

What is a Prostaglandin (-) that can be used to treat Diarrhea?

A

Bismuth

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3
Q

3 main classes of drugs to treat Diarrhea?

A

Opioid Agonists
Serotonin Antagonist
Cl- Channel Inhibitor

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4
Q

3 main classes of drugs to treat Diarrhea?

A

Opioid Agonists
Serotonin Antagonist
Cl- Channel Inhibitor

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5
Q

What are 3 Opioid Agonists to treat Diarrhea?

A

Loperamide
Diphenoxylate
Eluxadoline

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6
Q

What are 3 Opioid Agonists to treat Diarrhea?

A

Loperamide
Diphenoxylate
Eluxadoline

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7
Q

Does Loperamide exhibit analgesic/opiate-like effects?

A

No

- Nor physical dependence

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8
Q

MOA for Loperamide?

A

(Opioid Agonist)

= Acts on muscles of intestinal wall to slow/interfere with peristalsis

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9
Q

Possible adverse effects of Loperamide?

A

Cardiac toxicities leading to death
Anticholinergic effects
- Urinary retention, constipation, drowsy, blurred vision, etc.

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10
Q

Does Diphenoxylate exhibit analgesic/opiate-like effects?

A

Yes, at very high doses!

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11
Q

Diphenoxylate includes a small quantity of?

A

Atropine

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12
Q

Diphenoxylate includes a small quantity of?

A

Atropine

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13
Q

Why does Diphenoxylate have Atropine in it?

A

To discourage overdose/abuse

== Strong Anticholinergic effects!

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14
Q

MOA for Diphenoxylate?

A

(Opioid Agonist)

= Slows GI motility by acting on central/peripheral GI smooth muscle cells

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15
Q

What is the indication to use Eluxadoline?

A

IBS-D

irritable bowel syndrome - diarrhea subtype

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16
Q

Eluxadoline has 2 MOA. What are they?

A
  1. Agonist at mu and kappa receptors to slow peristalsis

2. Antagonist at delta receptors to decrease secretions

17
Q

Adverse effects of Eluxadoline?

A

Constipation
Hepatic/Pancreatic enzymes
CNS related

18
Q

Patients without a gallbladder on Eluxadoline are at an increased risk to develop?

A

Pancreatitis

19
Q

Contraindications for patients to take Eluxadoline?

A

Alcoholism/Hepatic impairment

Pancreatitis disease or NO gallbladder

20
Q

Which Opioid Agonist can treat IBS-D?

A

Eluxadoline

21
Q

What is a Serotonin Receptor Antagonist (5HT3) used to treat diarrhea?

A

Alosetron

22
Q

What is the indication to use Alosetron for Diarrhea?

A

Severe IBS-D that is NOT responsive to other treatments!!

23
Q

What is the indication to use Alosetron for Diarrhea?

A

Severe IBS-D that is NOT response to other treatments

24
Q

Adverse effect seen with Alosetron?

A

Ischemic Colitis

25
Q

Which drug to treat Diarrhea can cause Ischemic Colitis?

A

Alosetron

Serotonin Receptor 3 Antagonist

26
Q

You should not give your patients Alosetron if they have any?

A

GI or liver issues

27
Q

What is a Cl- Channel Inhibitor to treat Diarrhea?

A

Crofelemer

28
Q

What is a Cl- Channel Inhibitor to treat Diarrhea?

A

Crofelemer

29
Q

What is a Cl- Channel Inhibitor to treat Diarrhea?

A

Crofelemer

30
Q

What is the indication to give patients with Diarrhea Crofelemer?

A

Non-infectious diarrhea in HIV/AIDs patients on Anti-Retroviral Therapy!

31
Q

Crofelemer is given to what patients?

A

HIV/AIDS on ART

32
Q

HIV/AIDs patients with non-infectious diarrhea who are taking ART should be given what drug/class?

A

Crofelemer/Cl- Channel Inhibitor

33
Q

What drug for Diarrhea was derived from sap of a croton lechleri tree?

A

Crofelemer

34
Q

MOA for Crofelemer?

A

(-) Cl- secretion by blocking cAMP-stimluated CFTR and CaCC (calcium activated chloride channels)

35
Q

Crofelemer (-) Cl- secretion from channels. Which channels?

A

CFTR and CaCC

- (calcium activated chloride channels)

GI - 2 (61 decks)

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