H2 Antagonists and PPIs for PUD and GERD (anti-ulcer) Flashcards
H2 Receptor Antagonists (3)
Cimetidine
Famotidine
Nizatidine
H2 Receptor Antagonists (3)
Cimetidine
Famotidine
Nizatidine
Proton Pump Inhibitors (6)
Lansoprazole Dexlansoprazole Omeprazole Esomeprazole Pantoprazole Rabeprazole
Proton Pump Inhibitors (6)
Lansoprazole Dexlansoprazole Omeprazole Esomeprazole Pantoprazole Rabeprazole
MOA for H2 Receptor Antagonists?
Reversibly (-) H2 receptors on baso-lateral membrane of parietal cells
Drug class that (-) H2 receptors on baso-lateral membrane of parietal cells
H2 Receptor Antagonists
How quick is the onset for H2 Receptor Antagonists?
Pretty quick - 0.5-2 hours
= longer than antacids but shorter than PPIs
Common adverse effects of H2 Receptor Antagonists?
Primarily GI-related
Some CNS-related
RARE adverse effects of H2 Receptor Antagonists?
Neutropenia and Thrombocytopenia
Decreased testosterone binding to androgen receptor
== > Gynecomastia in males and Galactorrhea in females
Which H2 Receptor Antagonist has the potential to cause Gynecomastia in males and Galactorrhea in females and why?
Cimetidine
- Decreases Testosterone binding to androgen receptor
Which H2 Receptor Antagonist is a prototypical inhibitor of several CYP450 enzyme?
Cimetidine
Cimetidine has _____ of drug-drug interactions. Why?
LOTS
- Inhibits CYP450 enzymes
Relative contraindications for H2 Receptor Antagonists?
Pregnancy
MOA for Proton Pump Inhibitors?
Bind to Sulfhydryl groups of H+/K+ ATPase at parietal cell secretory sites
= (-) pumps and gastric acid secretion
Drug class that binds and inhibits H+/K+ ATPase on parietal cell secretory sites
Proton Pump Inhibitor
Proton Pump Inhibitors stop ____ secretion from parietal cells
Gastric acid secretion
How long does it take to see the effects of Proton Pump Inhibitors?
A few days
Common adverse effects of Proton Pump Inhibitors?
Primarily GI-related
Some CNS-related
RARE adverse effect of Proton Pump Inhibitors?
CDAD
- Clostridiodes Difficile - Associated Diarrhea
What drug class can cause CDAD (Clostridiodes Difficile - Associated Diarrhea)?
Proton Pump Inhibitors
Which Proton Pump Inhibitor is a prototypical inhibitor of CYP450?
Omeprazole
Omeprazole has ___ of drug-drug interactions. Why?
Lots
- Inhibits CYP450 enzymes
2 anti-ulcer drugs that have lots of drug-drug interactions because they inhibit CYP450 enzymes?
Cimetidine
Omeprazole
Relative Contraindications for Proton Pump Inhibitors?
Pregnancy
List the Proton Pump Inhibitors.
Lansoprazole Dexlansoprazole Omeprazole Esomeprazole Pantoprazole Rabeprazole
List the H2 Receptor Antagonists.
Cimetidine
Famotidine
Nizatidine
Relative Contraindications for H2 receptor antagonists and Proton Pump (-)?
Pregnancy
What is an isomer for the PPI Lansoprazole?
Dexlansoprazole
What is an isomer for the PPI Omeprazole?
Esomeprazole
Which PPIs have isomers?
Lansoprazole
Omeprazole
