Agents for IBD Flashcards
IBD
Inflammatory Bowel Disease
2 types of IBD?
Ulcerative Colitis
Crohn’s Disease
2 types of IBD?
Ulcerative Colitis
Crohn’s Disease
5 agent classes to treat Ulcerative Colitis?
- 5-ASA
- JAK (-)
- IL12/23 (-)
- TNF-alpha (-)
- Alpha-4 integrin (-)
3 agent classes to treat Crohn’s Disease?
- IL-12/23 (-)
- TNF-alpha (-)
- Alpha-4 integrin (-)
List the 5-ASA class members
Sulfsalazine
Mesalamine
Olsalazine
Balsalazide
List the 5-ASA class members
Sulfsalazine
Mesalamine
Olsalazine
Balsalazide
List the 5-ASA class members
Sulfsalazine
Mesalamine
Olsalazine
Balsalazide
List the JAK inhibitor
Tofacitinib
List the JAK inhibitor
Tofacitinib
List the JAK inhibitor
Tofacitinib
List the IL-12/23 inhibitor
Ustekinumab
List the IL-12/23 inhibitor
Ustekinumab
List the TNF-alpha inhibitors that treat both ulcerative colitis and crohn’s disease
Adalimumab
Infliximab
List the TNF-alpha inhibitors that treat both ulcerative colitis and crohn’s disease
Adalimumab
Infliximab
List the TNF-alpha inhibitor that can only treat ulcerative colitis
Golimumab
List the TNF-alpha inhibitor that can only treat ulcerative colitis
Golimumab
List the TNF-alpha inhibitor that can only treat crohn’s disease
Certolizumab
List the TNF-alpha inhibitor that can only treat crohn’s disease
Certolizumab
List the Alpha-4 integrin inhibitor that can treat both ulcerative colitis and crohn’s disease
Vedolizumab
List the Alpha-4 integrin inhibitor that can treat both ulcerative colitis and crohn’s disease
Vedolizumab
List the Alpha-4 integrin inhibitor that can only treat crohn’s disease
Natalizumab
List the Alpha-4 integrin inhibitor that can only treat crohn’s disease
Natalizumab
When should you use TNF-alpha inhibitors?
After an inadequate response to conventional or immunosuppressant therapy
When should you use IL-12/23 inhibitors?
After an inadequate response to conventional, immunosuppressant or TNF-alpha therapy
When should you use Alpha-4 integrin inhibitors?
After an inadequate response to conventional, immunosuppressant or TNF-alpha therapy
What can be used for uncontrolled, acute or severe ulcerative colitis/crohn’s disease?
Glucocorticosteroids
What 4 drugs can treat both Ulcerative Colitis and Crohn’s Disease?
Ustekinumab
Adalimumab
Infliximab
Vedolizumab
What 4 drugs can treat both Ulcerative Colitis and Crohn’s Disease?
Ustekinumab
Adalimumab
Infliximab
Vedolizumab
What 4 drugs can treat both Ulcerative Colitis and Crohn’s Disease?
Ustekinumab
Adalimumab
Infliximab
Vedolizumab