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GI - 2 > Agents for Constipation > Flashcards

Agents for Constipation Flashcards

1
Q

What are 4 classes of drugs to treat Constipation?

A
  1. Peripheral Opioid Antagonists
  2. Guanylate Cyclase-C Agonists
  3. Cl- 2 Channel Activator
  4. Serotonin 4 Partial Agonists
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2
Q

What are 4 classes of drugs to treat Constipation?

A
  1. Peripheral Opioid Antagonists
  2. Guanylate Cyclase-C Agonists
  3. Cl- 2 Channel Activator
  4. Serotonin 4 Partial Agonists
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3
Q

What are the Peripheral Opioid Antagonist Agents?

A

Methylnaltrexone
Naloxegol
Alvimopan

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4
Q

What are the Peripheral Opioid Antagonist Agents?

A

Methylnaltrexone
Naloxegol
Alvimopan

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5
Q

MOA for the Peripheral Opioid Antagonist Agents?

A

Peripherally acting mu receptor antagonists

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6
Q

What receptor do the Peripheral Opioid Antagonist Agents block?

A

mu

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7
Q

Peripheral Opioid Antagonists are indicated for?

A

Opioid Induced Constipation

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8
Q

What is Alvimopan only used to treat?

A

Prevent post-op Ileus

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9
Q

What Peripheral Opioid Antagonist is used to prevent post-op Ileus?

A

Alvimopan

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10
Q

Those on Alvimopan are at risk for?

A

MI

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11
Q

What is the Guanylate Cyclase-C Agonist?

A

Linaclotide

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12
Q

What is the Guanylate Cyclase-C Agonist?

A

Linaclotide

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13
Q

What is Linaclotide indicated for?

A

IBS-C and Chronic Idiopathic Constipation

irritable bowel syndrome - constipation subtype

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14
Q

What drug/class is indicated only for IBS-C and Chronic Idiopathic constipation?

A

Linaclotide/Guanylate Cyclase-C Agonist

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15
Q

What is the Chloride 2 Channel Activator?

A

Lubiprostone

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16
Q

What is the Chloride 2 Channel Activator?

A

Lubiprostone

17
Q

What drug to treat Constipation is a Prostaglandin E1 Derivative?

A

Lubiprostone

cl- 2 channel activator

18
Q

MOA for Lubiprostone?

A

Activates Cl- 2 channels to increase fluid secretion

19
Q

Lubiprostone can be used to treat?

A

Most of the constipation types

20
Q

What is the Serotonin type 4 Partial Agonist?

21
Q

What is the Serotonin type 4 Partial Agonist?

22
Q

What is Tegaserod indicated for?

A

IBS-C for women > 65

23
Q

What is Tegaserod indicated for?

A

IBS-C for women > 65

24
Q

MOA for Tegaserod?

A

Partial agonist for serotonin type 4 receptors

25
Q

Most of the drugs used to treat constipation are going to do what?

A

Increase fluid secretion and peristalsis

26
Q

This drug can prevent post-op ileus

27
Q

This drug can treat IBS-C in women older than 65

28
Q

This drug is a derivative of prostaglandin E1 and activates chloride 2 channels

A

Lubiprostone

29
Q

This drug is indicated to treat opioid-induced, IBS-C and Chronic idiopathic constipation?

A

Lubiprostone

30
Q

This drug is indicated to treat IBS-C and Chronic idiopathic constipation?

A

Linaclotide

GI - 2 (61 decks)

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