Laxative Agents

Question 1

5 classes of laxative agents?

Answer 1

1. Bulk forming
2. Stool softening
3. Stimulants
4. Saline agents
5. Osmotic agents

Question 2

5 classes of laxative agents?

Answer 2

1. Bulk forming
2. Stool softening
3. Stimulants
4. Saline agents
5. Osmotic agents

Question 3

5 items in the Bulk forming class?

Answer 3

Diet items
Psyllium
Methylcellulose
Carboxymethylcellulose
Ca++ Polycarbophil

Question 4

5 items in the Bulk forming class?

Answer 4

Diet items
Psyllium
Methylcellulose
Carboxymethylcellulose
Ca++ Polycarbophil

Question 5

MOA for Bulk forming class?

Answer 5

Increase bulk volume to increase GI motility

Question 6

Adverse effects of the Bulk forming class?

Answer 6

Bloating and obstruction

Question 7

Does the Bulk forming class have any drug interactions?

Answer 7

Yes - avoid co-administration

Question 8

2 drugs in the Stool Softening class?

Answer 8

Mineral oil
Docusate salts (na+ and ca++)

Question 9

2 drugs in the Stool Softening class?

Answer 9

Mineral oil
Docusate salts (na+ and ca++)

Question 10

MOA for the Stool Softening class?

Answer 10

Surfactants - soften/lubricate stool

Question 11

Does the Stool Softening class have laxative effects?

Answer 11

NO - just soften

Question 12

Mineral oil penetrates?

Answer 12

Stool to soften

Question 13

4 drugs in the Stimulants class?

Answer 13

Senna
Bisacodyl
Glycerin
Sodium Picosulfate

Question 14

4 drugs in the Stimulants class?

Answer 14

Senna
Bisacodyl
Glycerin
Sodium Picosulfate

Question 15

MOA for the Stimulants class?

Answer 15

Irritate enterocytes to stimulate peristalsis quickly

Question 16

Adverse effects of the Stimulants class?

Answer 16

Cramping

Senna = urine discoloration

Question 17

Which Stimulant can cause urine discoloration?

Answer 17

Senna

Question 18

Which Stimulant is used for Pre-Colonoscopy Bowel Prep?

Answer 18

Sodium Picosulfate

Question 19

3 Saline Agents?

Answer 19

Mg++, K+, Na+ salts

Question 20

3 Saline Agents?

Answer 20

Mg++, K+, Na+ salts

Question 21

MOA for the Saline and Osmotic Agents?

Answer 21

Retain water in the GI tract

Question 22

MOA for the Saline and Osmotic Agents?

Answer 22

Retain water in the GI tract

Question 23

All of the Saline Agents can be used in combination for?

Answer 23

Pre-Colonoscopy Bowel Prep

Question 24

What drug interactions do the Saline Agents have?

Answer 24

Diuretics – electrolyte imbalances

Question 25

In what 2 conditions should you use caution when giving Saline Agents due to the possibility of electrolyte imbalances?

Answer 25

Renal Disease

CHF/HTN

Question 26

In what 2 conditions should you use caution when giving Saline Agents due to the possibility of electrolyte imbalances?

Answer 26

Renal Disease

CHF/HTN

Question 27

4 Osmotic Agents?

Answer 27

Lactulose
Lactitol
Polyethylene Glycol
Sorbitol

Question 28

4 Osmotic Agents?

Answer 28

Lactulose
Lactitol
Polyethylene Glycol
Sorbitol

Question 29

Adverse effects of Osmotic Agents?

Answer 29

Electrolyte disturbances

Question 30

What Osmotic Agent can be used for severe liver disease (Hyperammonemia) and why?

Answer 30

Lactulose

- Traps Ammonia in GI due to pH change

Question 31

What Osmotic Agent can be used for severe liver disease (Hyperammonemia) and why?

Answer 31

Lactulose

- Traps Ammonia in GI due to pH change

Question 32

What Osmotic Agent can be used for Pre-Colonoscopy Bowel Prep?

Answer 32

Polyethylene Glycol

Question 33

What laxatives can be used for Pre-Colonoscopy Bowel Prep?

Answer 33

Sodium Picosulfate (Stimulant)
ALL Saline agents (mg++, k+, na+ salts)
Polyethylene Glycol (Osmotic agent)

Question 34

What laxatives can be used for Pre-Colonoscopy Bowel Prep?

Answer 34

Sodium Picosulfate (Stimulant)
ALL Saline agents (mg++, k+, na+ salts)
Polyethylene Glycol (Osmotic agent)