18-5 Flashcards
Autoimmune Hepatitis primarily affects?
Females
Which HLA’s are associated with Autoimmune Hepatitis?
DR3 - White
DR4 - Japanese
DRB1 - South Americans
Autoimmune Hepatitis involves an immune attack on hepatocytes. What cells make up the lymphocytic infiltrate in the liver?
CD4 and CD8 T cells
Which T cells activate B cells (autoantibodies) with Autoimmune Hepatitis?
CD4 T cells
A diagnosis of Autoimmune Hepatitis requires 4 things. What are they?
- Autoantibodies
- Increased serum IgG
- Exclusion of other etiologies
- Supportive Histo findings of the liver
A diagnosis of Autoimmune Hepatitis requires 4 things. What are they?
- Autoantibodies
- Increased serum IgG
- Exclusion of other etiologies
- Supportive Histo findings of the liver
There are 2 types of Autoimmune Hepatitis. Who is affected by each and what autoantibodies are common?
Type 1 - adults
= SMA and ANA
Type 2 - kids
= LKM-1 and ACL-1
There are 2 types of Autoimmune Hepatitis. Who is affected by each and what autoantibodies are common?
Type 1 - adults
= SMA and ANA
Type 2 - kids
= LKM-1 and ACL-1
What fluorescent staining pattern is seen with the ANA with Type 1 Autoimmune Hepatitis?
Homogenous or speckled
List the morphologic findings with Autoimmune Hepatitis
- Clusters of plasma cells
- Emperipolesis
- Rosettes
List the morphologic findings with Autoimmune Hepatitis
- Clusters of plasma cells
- Emperipolesis
- Rosettes
Emperipolesis
- Seen with Autoimmune Hepatitis
= Lymphocytes and plasma cells in the cytoplasm of hepatocytes
Rosettes
- Seen with Autoimmune Hepatitis
= Circular regenerative hepatocytes around a cannaliculus
Common progression of autoimmune liver diseases?
Cirrhosis
HCC
What treatment can cause remission for some Autoimmune Hepatitis patients?
Prednisone +/- Azathioprine
What are 2 Autoimmune Cholangiopathies?
Primary Biliary Cholangitis
Primary Sclerosing Cholangitis
Autoimmune Cholangiopathies are autoimmune disorders of?
Bile ducts