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GI - 2 > 18-2 > Flashcards

18-2 Flashcards

1
Q

Hepatitis A

A

RNA
Fecal - oral; Contaminated raw shellfish
Acute

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2
Q

What is the incubation period for Hepatitis A?

A

2-6 weeks

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3
Q

When is HAV shed in the stool?

A

2-3 weeks before and 1 week after onset of jaundice

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4
Q

Symptoms of Hepatitis A?

A

Fatigue, loss of appetite, jaundice

- Rash, arthralgia, immune complex mediated complications

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5
Q

Symptoms of Hepatitis A?

A

Fatigue, loss of appetite, jaundice

- Rash, arthralgia, immune complex mediated complications

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6
Q

What marker is (+) for Hepatitis A?

A

IgM

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7
Q

Hepatitis B

A

DNA
Blood; Needles; MOTHER TO BABY (vertical)
Rarely chronic

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8
Q

What is the incubation period for Hepatitis B?

A

2-26 weeks

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9
Q

What are the 4 main presentations for Hepatitis B infection?

A
  1. Acute Hepatitis –> recovery
  2. Acute liver failure with massive necrosis
  3. Chronic Hepatitis w/ or w/o cirrhosis
  4. Asymptomatic carrier
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10
Q

What are the 4 main presentations for Hepatitis B infection?

A
  1. Acute Hepatitis –> recovery
  2. Acute liver failure with massive necrosis
  3. Chronic Hepatitis w/ or w/o cirrhosis
  4. Asymptomatic carrier
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11
Q

What markers will be (+) with Hepatitis B?

A

(+) HBV DNA
(+) HBsAg
(+) HBcAg antibodies

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12
Q

What does the outcome of Hepatitis B infection depend on?

A

Immune response

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13
Q

Resolution is more likely with Hepatitis B infection if what immune response occurs?

A

CD4 and CD8 T cells release IFN-gamma

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14
Q

Hepatitis C

A

RNA
Blood; needles
CHRONIC

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15
Q

What is the incubation period for Hepatitis C?

A

4-26 weeks

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16
Q

Symptoms of Hepatitis C?

A

Asymptomatic

17
Q

Symptoms of Hepatitis C?

A

Asymptomatic

18
Q

Lab markers for Hepatitis C?

A

Fluctuating AST/ALT is seen with Chronic HCV

19
Q

What types of things can cause progression of HCV towards chronic HCV and cirrhosis?

A

Older males, alcohol, obesity and diabetes

20
Q

What is the reason that many are unable to eradicate HCV infection?

A

Genetic variants

21
Q

Morphology of ACUTE viral hepatitis?

A

Lymphocyte, plasma cell and eosinophil inflammatory infiltrate

22
Q

Morphology of ACUTE viral hepatitis?

A

Lymphocyte, plasma cell and eosinophil inflammatory infiltrate

23
Q

Necrosis or Apoptosis of hepatocytes with ACUTE viral hepatitis may occur. What quality of macrophages will be seen?

A

Pigmented

24
Q

Main morphologic sign with CHRONIC viral hepatitis?

A

Portal lymphocytic inflammation with fibrosis and scarring

25
Q

Main morphologic sign with CHRONIC viral hepatitis?

A

Portal lymphocytic inflammation with fibrosis and scarring

26
Q

Interface activity can be seen with CHRONIC viral hepatitis. What is that?

A

Inflammatory cells cross limiting plate and injure periportal hepatocytes

27
Q

Interface activity can be seen with CHRONIC viral hepatitis. What is that?

A

Inflammatory cells cross limiting plate and injure periportal hepatocytes

28
Q

Due to the fibrosis that occurs with CHRONIC viral hepatitis, what usually results?

A

Cirrhosis

29
Q

Main morphologic sign of CHRONIC HBV?

A

Ground glass hepatocytes

30
Q

Ground glass hepatocytes are seen with?

A

Chronic Hepatitis B

31
Q

What are ground glass hepatocytes?

A
  • seen with chronic hepatitis B

= swollen endoplasmic reticulum with HBsAg

32
Q

Main morphologic sign of CHRONIC HCV?

A

Lymphoid follicles in portal tract

33
Q

Lymphoid follicles in portal tract are seen with?

A

Chronic Hepatitis C

34
Q

Steatosis and bile duct injury are other common morphologic features of which chronic hepatitis?

A

C

35
Q

Portal lymphocytic inflammation with fibrosis and scarring is seen with what type of hepatitis?

A

CHRONIC

GI - 2 (61 decks)

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