17-3 -- Stomach Flashcards
The Gastric Mucosa has many factors that protect it. List 5.
- Prostaglandins
- Mucous secretion and mucosal blood flow
- Bicarbonate secretion
- Epithelial barrier and regenerative capactiy
The Gastric Mucosa has many factors that protect it. List 5.
- Prostaglandins
- Mucous secretion and mucosal blood flow
- Bicarbonate secretion
- Epithelial barrier and regenerative capacity
The Gastric Mucosa has many factors that can damage it. List 3.
- Acid
- Peptic enzymes
- Injury - ex. H.pylori, NSAIDs, alcohol
The Gastric Mucosa has many factors that can damage it. List 3.
- Acid
- Peptic enzymes
- Injury - ex. H.pylori, NSAIDs, alcohol
Acute Gastritis
Inflammation of gastric mucosa when Neutrophils are present
With Acute Gastritis, what inflammatory cell must be present?
Neutrophils
Gastropathy
Inflammation of gastric mucosa when NO inflammatory cells present
What causes Gastritis?
Damaging forces overwhelm the protective factors of the mucosa
What can cause Acute Gastritis?
NSAIDs, alcohol, bile
How do NSAIDs cause Acute Gastritis?
(-) COX = DECREASED prostaglandin synthesis
prostaglandin is a protective factor
What histo signs will be present with Acute Gastritis?
Foveolar cell hyperplasia, edema
Neutrophils above the basement membrane
2 types of Chronic Gastritis and what causes them?
Type A - autoimmune
Type B - H.pylori
Type A Chronic Gastritis has what blood change?
Hypergastrinemia
Type A Chronic Gastritis location and damage?
Body and fundus of stomach
= Diffuse mucosal damage
Type A Chronic Gastritis has antibodies to?
Parietal cells and Intrinsic factor
= Decreased acid ==> Hypergastrinemia trying to compensate