17-7 -- IBS/IBD Flashcards

1
Q

IBS

A

Irritable Bowel Syndrome

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2
Q

Symptoms of IBS?

A

Relapsing abdominal pain, bloating and changes in bowel habits

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3
Q

Relapsing abdominal pain, bloating and changes in bowel habits

A

IBS

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4
Q

Microscopic evaluations of IBS?

A

NORMAL

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5
Q

Most common people affected by IBS/IBD

A

Females 20-40 in high income countries

Ashkenazi Jews

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6
Q

For IBS, there is interplay between stressors, diet, abnormal GI motility and increased enteric sensory responses. What are 2 possible etiologies for IBS?

A

Excessive bile acid = IBS-D

Defective brain-gut signaling axis

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7
Q

For IBS, there is interplay between stressors, diet, abnormal GI motility and increased enteric sensory responses. What are 2 possible etiologies for IBS?

A

Excessive bile acid = IBS-D

Defective brain-gut signaling axis

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8
Q

2 types of IBD?

A

Ulcerative Colitis

Crohn Disease

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9
Q

Inappropriate immune activation against intestinal microbiota is seen with?

A

IBD

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10
Q

What 2 food changes are thought to increase IBD?

A

Increased food hygiene and preservatives

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11
Q

Crohn Disease - location

A

Ileum and Colon

= skip lesions

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12
Q

Ulcerative Colitis - location

A

Rectum and continuous colon involvement

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13
Q

Crohn Disease is patchy and often termed ___ lesions

A

Skip lesions

- ileum and colon

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14
Q

Crohn Disease has ____ inflammation

A

Transmural

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15
Q

Ulcerative Colitis has _____ inflammation

A

Mucosal

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16
Q

Something unique to Crohn Disease?

A

Creeping fat

= fat extends over serosa

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17
Q

Something unique to Ulcerative Colitis?

A

Pseudopolyps

= bulging mucosa

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18
Q

Ulcers may present with both types of IBD. Describe the differences in them.

A

Crohn - DEEP ulcers

Ulcerative Colitis - SUPERFICIAL

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19
Q

Marked Fibrosis and Serositis with possible fistulas occurs with what IBD type?

A

Crohn Disease

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20
Q

Crohn Disease bowel anatomical changes?

A

THICK walls with possible strictures present

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21
Q

What does the Mucosa look like in Ulcerative Colitis?

A

Red, granular with broad ulcers

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22
Q

If the Pseudopolyp tips fuse with Ulcerative Colitis, what does that create?

A

Mucosal bridges

23
Q

What polymorphism may be present in some cases of Crohn Disease?

24
Q

What is the earliest lesion with Crohn Disease?

A

Aphthous ulcers

25
The earliest lesion with Crohn Disease progresses how?
Aphthous ulcers coalesce to form an elongated, serpentine ulcer running along the axis of the bowel
26
Crohn Disease often has a _____ appearance
Cobblestone
27
Crohn Disease and ulcerative Colitis - mucosal changes
Crohn - edema and loss of mucosal folds | Ulcerative Colitis - Mucosal atrophy
28
Iron deficient anemia, along with malabsorption and hypoalbuminemia can present with?
Crohn Disease
29
Severe initial attack is seen with which IBD?
Ulcerative colitis
30
Both IBD have intermittent diarrhea, abdominal pain, RLQ pain. What is more severe and seen with Ulcerative Colitis?
Bloody diarrhea attacks with stringy mucoid material | Cramps relieved by defection
31
2 other causes of Chronic Colitis?
Diversion Colitis | Microscopic Colitis
32
2 other causes of Chronic Colitis?
Diversion Colitis | Microscopic Colitis
33
Describe how Diversion Colitis arises
Some GI disorders require a creation of an ostomy (blind distal segment of colon) from which fecal flow is diverted -- Colitis can develop in diverted segment
34
Describe how Diversion Colitis arises?
Some GI disorders require a creation of an ostomy (blind distal segment of colon) from which fecal flow is diverted -- Colitis can develop in diverted segment
35
Main sign of Diversion Colitis?
Numerous Mucosal Lymphoid Follicles
36
Numerous mucosal lymphoid follicles could indicate?
Diversion Colitis
37
2 types of Microscopic Colitis?
Collagenous Colitis | Lymphocytic Colitis
38
Collagenous Colitis
Watery diarrhea without weight loss in middle aged women
39
Water diarrhea without weight loss in middle aged women
Collagenous Colitis | Type of Microscopic Colitis
40
Lymphocytic Colitis
Watery diarrhea without weight loss in autoimmune/celiac disease
41
Watery diarrhea without weight loss in autoimmune/celiac disease
Lymphocytic Colitis | Type of Microscopic Colitis
42
Graft Vs. Host Disease occurs following?
HSC transplant
43
What are destroyed with Graft Vs. Host Disease?
Crypts
44
Symptoms of Graft vs. Host Disease?
Water to bloody diarrhea
45
What is Sigmoid Diverticular Disease?
Acquired pseudodiverticular outpouchings of the colonic mucosa and submucosa
46
Acquired pseudodiverticular outpouchings of the colonic mucosa and submucosa
Sigmoid Diverticular Disease
47
US common site of Diverticular Disease?
Left colon
48
Africa/Asia common site of Diverticular Disease?
Right colon
49
Pathogenesis of Sigmoid Diverticular Disease?
Unique structure of mucularis propria + increased intraluminal pressure
50
Increased intraluminal pressure can lead to?
Sigmoid Diverticular Disease
51
Symptoms of Sigmoid Diverticular Disease?
Asymptomatic Cramping and abdominal discomfort with intermittent constipation/diarrhea - Sensation of never fully emptying the rectum
52
Symptoms of Sigmoid Diverticular Disease
Asymptomatic Cramping and abdominal discomfort with intermittent constipation/diarrhea - Sensation of never fully emptying the rectum
53
Sensation of never fully emptying the rectum can be seen with?
Sigmoid Diverticular Disease