RHEUMATOID ARTHRITIS Flashcards
Disease of the synovium with gradual inflammatory joint destruction
RHEUMATOID ARTHRITIS
Types of RA depending on rheumatoid factor
sero-negative (present)
sero-positive (not present)
where does RA initially start
hands and feet
RA feature
symmetrical
onset with systemic symptoms
early signs of RA
symmetrical synovitis of MCP, PIP, wrist joints
late signs of RA
finger deviation
hyperextension of PIP joints
Z thumbs
wrist subluxation
loss of shoulder rotation
feet and ankle deformity
extra-articular features of RA
systemic vasculitis
psoriasis
scleritis and episcleritis
sjogrens
amyloidosis
RA investigations
loss of joint space, deformity, joint destruction
normochromic normocytic anaemia
drugs for RA
analgesics
NSAIDs
methotrexate, hydrochloroquine
steroids: oral prednisolone
immune modulators: azathrioprine, mycophenolate
biologics: rituximab and tocilizumab
atlanto-occipital instability
slipping and rupturing of ligaments, spinal damage
types of seronegative spondlyoarthritis
ankylosing spondylitis
reiters disease
arthritis of IBD
Ankylosing spondylitis associated protein
HLA B27
AS features
infection
symmetrical peripheral arthritis
ocular and mucocutaneous manifestations
AS features
progressive lack of axial movement
symmetrical joint involvements e.g., hips
lower back pain, limited back and neck movement, limited chest expansion
spine tipped forward
AS tx
analgesia and NSAIDs
physiotherapy
occupational therapy
DMDs
immune modulators
surgery
