INHERITED BLEEDING DISORDERS

Question 1

inherited bleeding disorders can affect

Answer 1

1. coagulation cascade
2. platelets
3. both

Question 2

haemophilia

Answer 2

too little clot formed

Question 3

thrombophilia

Answer 3

too much clot formed

Question 4

factor VII def

Answer 4

haemophilia/ A

Question 5

Factor IX def

Answer 5

christmas disease
Haemophilia B

Question 6

reduced factor VII and reduced platelet aggregation

Answer 6

von willebrands disease

Question 7

DDAVP

Answer 7

desmopressin
releases factor VIII to boost factor VII levels and clotting ability

Question 8

tranexamic acid

Answer 8

inhibitor of fibrinolysis - keeps any clot that is formed

Question 9

Haemophilia A and B affects who

Answer 9

sex linked recessive - males affected, females carriers
defect gene on X chromosome

Question 10

management of haemophilia A

Answer 10

severe and mod - recomb factor VIII
mild and carriers - DDAVP/ tranexamic acid

Question 11

management of haemophilia B

Answer 11

severe and mod - recomb factor IX
mild and carriers - recomb factor IX

Question 12

Von wilebrand disease affects who

Answer 12

autosomal dominant
not transmitted on X chromosome
both sexes equally affected

Question 13

mild types of VW

Answer 13

1 and 2 (dominant)

Question 14

severe types of VW

Answer 14

type 3 (recessive)

Question 15

management of VW

Answer 15

severe and mod - DDVAP
mild and carriers - oral tranexamic acid

Question 16

special care required for what dental tx

Answer 16

LA
XLA
minor oral surg
perio surg
biopsies

Question 17

safe LA

Answer 17

buccal infil
intraligamentary
intrapapillary

Question 18

not safe LA

Answer 18

IAN block
lingual infil
post sup nerve block

Question 19

Thrombophilia

Answer 19

increased risk of clots developing

Question 20

thrombophilia risk

Answer 20

pulmonary thromboembolism

Question 21

inherited hypercoagulation causes

Answer 21

protein C def
protein S def
factor V leiden
antithrombin III def

Question 22

acquired hypercoagulation causes

Answer 22

antiphospholipid syndrome
oral contraceptives
surgery, trauma, cancer, pregnancy, immobilisation

Question 23

thrombocytopenia

Answer 23

reduced platelet numbers

Question 24

platelet count aim for dental tx

Answer 24

100x 10 9 / L

Question 25

qualitative disorders

Answer 25

normal platelet number but abnormal function

Question 26

thrombocythemia

Answer 26

increased platelet numbers

Question 27

what do pts with thrombocythemia normally take

Answer 27

aspirin to prevent clots