IBD Flashcards
IBD categories
Crohn’s
Ulcerative colitis
crohn’s presentation
abdominal pain
diarrhoea
perianal disease
UC presentation
diarrhoea and bleeding
IBD causes
genetic predisposition
mucosal immune system
environmental triggers
what gene is affected in IBD
NOD2/ CARD15 (IBD-1)
effective tx for peri-anal crohns disease
antibiotics
what is the main cytokine in control of proinflammatory response
Interferon gamma (Th1 cytokine)
what environmental factors aggravate crohns
smoking
what drug causes IBD flare up
NSAIDs
UC
inflammation of the colon
affects rectum and extends proximally
determining severity of UC
Truelove and Witt criteria
more than 6 bloody stools in 24hours plus 1/more of:
- fever
- tachycardia
- anaemia
- elevated ESR
Blood tests for UC
looks for C-reactive protein, albumin, and platelets
UC histology
loose goblet cells and expansion on crypts which results in abscess formation
What does crohns disease affect
any area of GI tract from mouth to anus
crohns disease causes
transmural inflammation of the bowel wall and skip lesions
