LYMPHOMA Flashcards
what does the haempoietic system start with
pluripotent stem cells
what are the two haemopoietic lingeages
myeloid
lymphoid
lymphoma
clonal proliferation of lymphocytes arising in a lymph node/ associated tissue
- solid tumour but some cells are in the blood
types of lymphoma
hodgkin
non hodgkin
lymphoma staging
number of nodes involved and site
extra nodal involvement
systemic symptoms
hodgkin lymphoma peak incidence
15-40 years
Hodgkin lymphoma symptoms
painless lymphadenopathy - fluctuate in size, pain with alcohol
fever, night sweats, weight loss, itching, infection
non hodgkin lymphoma peak incidence
any age
what is non-hodgkin lymphoma associated with
EBV, HIV, H.Pylori
autoimmune diseases
immunosuppression
autoimmune diseases associated with non-hodgkin lymphoma
Sjogrens
RA
PUD
Non hodgkin lymphoma presentation
lymphadenopathy
extra nodal disease
symptoms of marrow failure
constitutional symptoms less common
extra nodal diseases involved with non-hodgkin lymphoma
oropharyngeal involvement
Waldeyer’s ring
multiple myeloma mean age
70
multiple myeloma
malignant proliferation of plasma cells
multiple myeloma results in
monoclonal paraprotein in blood and urine
lytic bone lesions; pain and fracture
excess plasma cells in bone marrow; marrow failure
multiple myeloma effects
infection
bone pain
renal failure
amyloidosis
Tx of haematological malignancies
chemotherapy
radiotherapy
monoclonal antibodies
haemopoietic stem cell transplantation
chemotherapy target
cells with high turnover
effects of chemo
bad side effects
long-term risk of oncogenesis
effects of radiotherapy
cytotoxic effect of ionising radiation
healthy tissue also irradiated
risk of late cancer
monoclonal antibody target
specific cell types through interleukin messaging, growth factors
supportive therapy
nutrition
psychological and social support
prevention and tx of infection
managing symptoms of therapy side effects
correcting marked blood components deficits
pain control