LYMPHOMA

Question 1

what does the haempoietic system start with

Answer 1

pluripotent stem cells

Question 2

what are the two haemopoietic lingeages

Answer 2

myeloid
lymphoid

Question 3

lymphoma

Answer 3

clonal proliferation of lymphocytes arising in a lymph node/ associated tissue
- solid tumour but some cells are in the blood

Question 4

types of lymphoma

Answer 4

hodgkin
non hodgkin

Question 5

lymphoma staging

Answer 5

number of nodes involved and site
extra nodal involvement
systemic symptoms

Question 6

hodgkin lymphoma peak incidence

Answer 6

15-40 years

Question 7

Hodgkin lymphoma symptoms

Answer 7

painless lymphadenopathy - fluctuate in size, pain with alcohol
fever, night sweats, weight loss, itching, infection

Question 8

non hodgkin lymphoma peak incidence

Answer 8

any age

Question 9

what is non-hodgkin lymphoma associated with

Answer 9

EBV, HIV, H.Pylori
autoimmune diseases
immunosuppression

Question 10

autoimmune diseases associated with non-hodgkin lymphoma

Answer 10

Sjogrens
RA
PUD

Question 11

Non hodgkin lymphoma presentation

Answer 11

lymphadenopathy
extra nodal disease
symptoms of marrow failure
constitutional symptoms less common

Question 12

extra nodal diseases involved with non-hodgkin lymphoma

Answer 12

oropharyngeal involvement
Waldeyer’s ring

Question 13

multiple myeloma mean age

Answer 13

70

Question 14

multiple myeloma

Answer 14

malignant proliferation of plasma cells

Question 15

multiple myeloma results in

Answer 15

monoclonal paraprotein in blood and urine
lytic bone lesions; pain and fracture
excess plasma cells in bone marrow; marrow failure

Question 16

multiple myeloma effects

Answer 16

infection
bone pain
renal failure
amyloidosis

Question 17

Tx of haematological malignancies

Answer 17

chemotherapy
radiotherapy
monoclonal antibodies
haemopoietic stem cell transplantation

Question 18

chemotherapy target

Answer 18

cells with high turnover

Question 19

effects of chemo

Answer 19

bad side effects
long-term risk of oncogenesis

Question 20

effects of radiotherapy

Answer 20

cytotoxic effect of ionising radiation
healthy tissue also irradiated
risk of late cancer

Question 21

monoclonal antibody target

Answer 21

specific cell types through interleukin messaging, growth factors

Question 22

supportive therapy

Answer 22

nutrition
psychological and social support
prevention and tx of infection
managing symptoms of therapy side effects
correcting marked blood components deficits
pain control