CONNECTIVE TISSUE DISEASE Flashcards
Name the multisystem vasculitic inflammatory diseases
systemic lupus erythematous (SLE)
systemic sclerosis (scleroderma)
Sjogren’s syndrome (SS)
undifferentiated connective tissue disease (UCTD)
types of vasculitic diseases
large vessel disease - giant cell (temporal) arteritis
medium vessel disease - polyarteritis nodosa, kawasaki disease
small vessel disease - wegners granulomatosis
general medication for pain
analgesics
NSAIDs
immune modulating drugs
hydroxychloroquine
methotrexate
azathioprine
mycophenolate
biologics
systemic steroid eg
prednisolone
lupus antibodies
ANA
dsDNA
Ro
lupus features
butterfly rash on face
lung, heart, kidney problems
arthritis and raynauds
what does lupus result in which affects oral ulceration
chronic anaemia
what oral effect foes hydroxychloroquine have
pigmentation
antiphospholipid antibody syndrome effect
recurrent thrombosis
can you stop anticoagulant intake for someone with APS
NO
Groups of sjogrens
sicca syndrome
primary sjogrens
secondary sjogrens
what type of sjogrens is associated with dry eyes
sicca syndrome
what type of sjogrens isnt associated with any other disease
primary
what type of sjogrens is associated with another connective tissue disease
secondary
systemic sclerosis
excessive collagen deposition, connective tissue fibrosis and loss of elastic tissue
local systemic sclerosis antibodies
anticentromere
generalised systemic sclerosis antibodies
anti scl-70
what disease may systemic sclerosis result in
raynauds
renal failure
malabsorption
dental aspects of systemic sclerosis
perioral tissue involvement
SJOGRENS
dysphagia and reflux oesophagitis
widened PDL
Vasculitis
inflammation of blood vessels and infarction of tissue
how may vasculitis present in the mouth
oral inflammatory masses
ulcers
what do pt polymyalgia rheumatica also usually have?
giant cell arteritis - large vessel disease
polymyalgia rheumatica presentation
headache/ facial pain
chewing claudication and blindness
muscle morning pain
non-specific systemic features
poylmyalgia rheumatica tx
steroids
polyarteritis nodosa
medium vessel disease
kawasaki disease
polyarteritis nodosa
‘mucocutaneous lymph node syndrome’
kawasaki disease presentation
fever
lymphadenopathy
crusting/ cracked tongue
strawberry tongue and red mucosa
peeling rash on hands and feet
wegeners granulomatosis
small vessel disease
wegeners granulomatosis presention
destruction of hard and soft facial tissues
spongy red tissue
wegeners granulomatosis antibodies
ANCA
what other systems does wegeners granulomatosis affect
resp
renal
fibromyalgia
non-specific collection of musculoskeletal symptoms - pain all over body
main tx of vasculidities
steroids
