ANAEMIA Flashcards

1
Q

Anaemia

A

reduction of haemoglobin in the blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

how do haemoglobin issues arrise

A

inability to make the haem (iron def)
inability to make the correct globin chains (sickle cell)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

anaemia causes

A
  1. reduced production
  2. increased losses
  3. increased demand
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

reduced production of haemoglobin

A

nutrition
malabsorption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

increased losses of haemoglobin

A

blood loss
intravascular haemolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

increase haemoglobin demand

A

increased utilisation - pregnancy, growth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

disease reducing iron absorption

A

achlorydia
coeliac disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

achlorhydia

A

lack of stomach acid
no conversion of non-haem iron

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

diseases causing iron loss

A

gastric erosions/ ulcers
IBD
Bowel cancer
haemorrhoids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

causes of Vit B12 def

A

lack of intake - vegans
lack of intrinsic factor - pernicious anaemia
disease of terminal ilium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

lack of intrinsic factor due to

A

autoimmune stomach disease (pernicious anaemia)
gastric disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

disease of terminal ilium

A

crohns diasease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

folic acid def cause

A

lack of intake
absorption failure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

absorption failure of folic acid cause

A

jejunal disease (coeliac)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

abnormal globin chains

A

sickle cell
thalassaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

thalassaemia

A

normal haem production
genetic mutation of globin chains

17
Q

clinical effects of thalassaemia

A

chronic anaemia
marrow hyperplasia - skeletal deformities
splenomegaly
cirrhosis
gallstones

18
Q

thalassaemia management

A

blood transfusion
prevent iron overload

19
Q

sickle cell anaemia

A

abnormal globin chains

20
Q

sickle cell anaemia effects

A

haem change shape in low 02 environments
prevent RBC from passing through cappilaries
tissue ischaemia (pain and necrosis)

21
Q

measure degree of anaemia

A

measure Hb

22
Q

measure cell deficiency or Hb formation def,

A

RCC and HCT

23
Q

measure overall picture

A

MCV
(size of cell)

24
Q

types of anaemia RCC and HCT losses

A

lose normal red cells through bleeding - GI
abnormal red cells with reduced lifespan and removed by spleen - autoimmune/ hereditary

25
Q

anaemia classifications

A

microcytic
macrocytic
normocytic
hypochromic
ansiocytic

26
Q

ansiocytic

A

exaggerated sizes of cells
really big and really small

27
Q

reticulocyte

A

almost mature RBC - released early into circulation to replace losses

28
Q

reticulocytosis effect

A

raised MCV

29
Q

anaemia signs

A

pale
tachycardia
enlarged liver and spleen (RARE)
pale mucosa
smooth tongue
angular cheilitis
beefy tongue

30
Q

anaemia symptoms

A

tired and weak
dizzy
SOB
palpitations

31
Q

anaemia investigations

A

good history
FBC
GI blood loss - FOB, endoscopy/ colonoscopy
Renal function
Bone marrow exam

32
Q

anaemia Tx

A

replace haematinics
transfusions
erythropoietin

33
Q

replacing haematinics

A

FeSO4 200mg tds for 3 months
1mg IM vitB12 x 6 then 1mg/2 months
5mg folic acid daily

34
Q

production failure/ renal disease tx

A

erythropoietin