Perio III Flashcards
There are more bacteria than cells in a human body by a factor of _____
20
Undisturbed oral biofilm grows at ____to _____ micrometers/day
82 - 200
T/F
CHX can affect plaque that’s been in place from 24-48 hours.
T/F
CHX can affect 6 hour plaque
False
True
If PD is over 7mm, what is the average reduction in PD after Scaling and Root Planing?
2.16 mm
If PD is over 7mm, what is the average reduction CAL after Scaling and Root Planing?
1.19 mm
What is the main function of Scaling/Root Planing?
Decreases surface area
What is the deepest Scaling and Root Planing generally goes on the root?
5 mm
*even if PD much bigger than 5 mm
6 problems of Restricted Access when Scaling/Root planing
PD
Furcations
Root Proximity
Root Flutings
CEJ relationships
Restorations
Periodontal _____ lesions can limit soft tissue management
Infrabony
Perio OHI clinical protocol:
3 items
Electric toothbrush
Waterpik (or floss)
CHX 2x/day
SRP is part of Perio clinical protocol and is done with ______
local anesthesia
What low dose antibiotic is preferred?
What is the dose?
Doxycycline
20 mg
When is the re-eval post-SRP?
4-6 weeks
At 4-6 weeks SRP, what sites are re-treated after re-eval?
In what 2 ways?
greater than 5 mm
SRP, Site-specific drugs
When are surgical treatments considered in the Perio Clinical Protocols?
Post re-eval, after second SRP, site specific drugs, etc if response not achieved
Low Dose Doxycycline (originally Periostat) is 20 mg doxy, _____ tabs, every ____ hours
180 tabs
12 hours
20 mg concentration of doxy has no bacterial effect, but does chelate metals (Ca, Zn, Mg) and inactivates ________
Matrix metalloproteinases
The matrix metalloproteinases inactivated by low dose Doxy are what 2 specific products?
Produced by what 2 specific cells?
Gelatinases, Collegenases
PMN’s, Macrophage
*so low-dose Doxy fights our own immune system and its degrading factors
When is it appropriate to use SRP + Local delivery?
Post re-eval
6 conditions SRP + local delivery can be used:
Pockets greater than 5mm
Maintenance PD 5-6mm
Early perio abscess
PD distofacial 2M’s for 3M extraction
Ailing implants
Furcations
3 locally delivered Antimicrobials (brand names)
PerioChip
Atradox
Arestin
What is in PerioChip:
Atradox:
Arestin:
CHX
Doxycycline (gel)
1 mg minocycline (powder)
T/F
In terms of reaching the disease site, achieving adequate concentration and duration, killing the target microbe, and not harming the patient, Locally Delivered antimicrobials are the best
(when compared to mouth rinse, subgingival irrigation, and systemic antibiotics)
True
Arestin is __mg of _____ in powder
1 mg
minocycline
GCF concentration minocycline after Arestin therapy:
3 days out:
14 days:
28 days:
90,000 ug/ml
3250 ug/ml
340 ug/ml
10-20 ug/ml
5 bacteria that are susceptible to minocycline (Arestin) concentrations at 2-8 ug/ml
P. gingivalis
P. intermedia
F. nucleatum
E. corrodens
A.a.
Low dose doxy targets cytokines, prostanoids, MMP’s and therefore inhibits _____ and _____ metabolism
CT
bone
T/F
Local antimicrobial + Low Dose Doxy goes after both microbial challenge and CT/Bone metabolism
True
It is possible to get a pocket reduction of 3mm, but more realistically it will be ____mm.
Pocket reduction of ___mm is not realistic
2mm
4mm
Open Flap Debride can get a Pocket Reduction of ___mm
3.00
SRP + Arestin reduction in PD:
SRP + Atridox:
SRP + PerioChip:
- 65 mm
- 2 mm
- 9 mm
(bout half mm less reduction in CAL)
What systemic antibiotic is the drug of choice in treatment of Agressive Perio?
Amoxicillin
Other than Amoxicillin, name 6 drugs prescribed for Aggressive Perio:
Metronidazole (NOT w/ EtOH)
Tetracycline (photosentitive)
Doxy
Clindamycin
Amoxicillin + Clavulanic Acid (Augmentin)
Azithromycin (Z-pak not used much any more)
T/F
The advantages of systemic antibiotics is wide dispersement, reduction of chair time to treat pts, and a wide range of drugs to choose from.
True
What is the primary disadvantage to systemic antibiotic use for chronic perio?
pt compliance
Aside from compliance, allergy, GI problems, DDI’s, cost and the inability to penetrate intact ______ are disadvantages for systemic antibiotic use for chronic perio.
biofilm
T/F
Frequency (of taking drug) and compliance are inversly related
True
GI, nausea, photosensitivity, bacterial resistance, _____, and ______, are common side effects of systemic antibiotics.
Esophagitis
Candidiasis