Orathon3: Adventures in Pathology Flashcards
A white patch or plaque that Won’t rub off and which can’t be diagnosed as any specific condition. A Clinically descriptive term.
Leukoplakia
2 etiologies of Leukoplakia:
Frictional Keratosis (physical)
Tobacco (most)
80% of Leukoplakia is _____, _____, and ______
17% is ______
3% is _____
Hyperparakeratosis, Hyperorthokeratosis, Acanthosis (increased thickness)
Epithelial dysplasia/carcinoma in situ (pre-malignant)
Superficially invasive squamous cell carcinoma
Superficially Invasive Squamous Cell Carcinoma makes up ____% of __________,
3%, Leukoplakia
Superficialy invasive squamous cell carcinoma (3% of Leukoplakia), a single incisional biopsy will underdiagnose ___%, and surgical excision will display carcinoma ___%
Multiple biopsies will underdiagnose ____%, carcinoma __%
30%, 12%
12%, 2.4%
3 most common anatomic sites for Leukoplakia:
% of time Dysplastic/Invasive for each
Floor mouth/ventral tongue (50%)
Lateral Tongue (25%)
Lower lip (35%)
There is homogenous Leukoplakia and Non-homogenous leukoplakia, which makes up ____ % of dysplastic/invasive
50-80%
3 types of Non-homogenous Leukoplakia:
Erythroleukoplakia (Erosive)
Nodular leukoplakia (Speckled)
Verrucous leukoplakia
The Rare form of progressive leukoplakia that is characterized by progression, multifocality, verrucous morphology, recurrence after excision, progression to SCC and death
Proliferative Verrucous Leukoplakia
Leukoplakia Malignant trasfromation _____ overall:
____% if dysplastic
____% if NOT dysplastic
4-6%
15%
1-3.5%
A red patch which can’t be diagnosed as a specific condition
clinically descriptive term considerable less common than leukoplakia
Erythroplakia
T/F
Erythroplakia has a tendency for high risk sites and may produce symptoms
True
Histology of Erythroplakia
Dysplasia
Carcinomainsitu/carcinoma
*almost 100%
Tx of Erythroplakia depends on presence/absence of what?
dysplasia
*severity
% if Erythroplakia resolves with Smoked tobacco cessation:
spit/topical tobacco cessation:
50%
95%
4 Premalignant conditions of Erythroplakia:
Sideropenic dysphagia
Submucous fibrosis
Lichen planus (controversial)
Immunosuppression
Oral Cancer: (known as what 2 things)
Squamous Cell Carcinoma
Epidermoid Carcinoma
SCC represents greater than ___% of all oral cancer
90%
90% of Oral Cancer is SCC. 10% is made up of what 3 types?
carcinoma/adenocarcinoma (salivary, metastatic)
Sarcoma
Leukemia/Lymphoma
How many new cases of SCC diagnosed/year?
How many will die?
30,000
9,000
Average 5 yr survival rate for oral SCC is less than
50%
Oropharyngeal cancer survival is (represents 1/3):
Oral cavity cancer survival is (represents 2/3):
*these 2 are computed together = 63%
90%
49.5%
Oral cavity cancer (SCC) has the __th lowest survival rate of any cancer
6th
T/F
Survival rates of oral cancer aren’t improving
Represent 4th most common cancer in black males
6th most common cancer in white males
True