Immunology I Flashcards
In blood, what suspends the free cells?
Plasma
What is Plasma minus the clotting factors?
Serum
What is the relative volume of Plasma/Cells?
Cells - 45% (this is called the hematocrit)
Plasma - 55%
What is the Leukocyte composition of the hematocrit?
1% (or so)
What does Plasma contain?
inorganic salts
Albumins
Globulins
Fibrinogen
What is the most abundant protein in Plasma that prevents edema?
Albumin
What is the function of Albumin?
they are Transport Proteins
Prevents edema
What Plasma protein serves to transport hormones, metals, and lipids, a subclass of which make up the antibodies?
Globulins
What subclass of globulins make up the circulating antibodies?
Gamma Globulins
What is the circulating clotting factor?
Fibrinogen
> Fibrin
What are the 3 main cell types of the hematocrit?
Erythrocytes
Thrombocytes
Leukocytes
What 2 categories of Leukocytes are there?
Granulocytes
Agranulocytes
What are the 3 Granulocytes?
Neutrophils
Eosinophils
Basophils
What are the 3 Agranulocytes?
Monocytes
Lymphocytes
Macrophage
What does the bone marrow do to form blood cells?
Hemopoiesis
Where does hematopoiesis occur early in fetal development?
Later in fetal development?
Yolk sac (mesenchyme)
Liver, spleen, lymph
If hematopoietic bone marrow is destroyed, where might hematopoiesis resume?
Liver and spleen
Where are lymphocytes made after puberty?
Lymphocytes
*after involution of thymus
What are the 2 major cell lineages from the Hematopoietic Stem Cell?
Lymphoid (B and T cells)
Erthromyeloid
RBCs, monocytes, neutrophils, eosinophils, basophils, and megakaryocytes
How many heme groups in hemoglobin?
4
What determines the Hemoglobin type?
the chain subtypes making up the tetramer
*HbA, HbA2, HbF
What type of chains make up HbA?
2 alpha
2 beta
What type of chains make up HbA2?
2 alpha
2 delta
What type of chains make up HbF?
2 alpha
2 gamma