Gynaecology_Breast Mass Flashcards

1
Q

On breast exam, which positions are used to aid with the inspection of breasts?

A
  • Seated with arms to the side
  • arms over the head (to expose the lateral and inferior aspects of the breast)
  • hands pressed against hips (contracting the pectoral muscles can cause dimpling of the skin suggesting that a tumor has entrapped a Cooper ligament)
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2
Q

what can be observed while visually inspecting breasts?

A
  • Symmetry
  • breast contour looking for masses
  • skin retraction or skin dimpling
  • skin color and texture
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3
Q

During the breast exam, when should lymph nodes be palpated?

A

When the patient is seated, the axillary fat pad moves anterior exposing the axillary lymph nodes (but don’t forget to palpate the infraclavicular and supraclavicular lymph nodes as well).

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4
Q

Describe the examination of breasts while the patient is supine.

A
  • The patient’s ipsilateral arm should be placed above the head.
  • Palpate the breast tissue with the second, third, and fourth finger pads.
  • Other hand supports the breast tissue.
  • Move finger pads in a systematic fashion (spiral pattern from the nipple to the outer breast or a vertical strip pattern).
  • Compress each nipple between your thumb and index fingers, and inspect for discharge.
  • Examine the contralateral side.
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5
Q

In which quadrant is breast cancer typically found?

A

upper, outer quandrant

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6
Q

What two entities comprise breast lumps?

A
  1. Cysts
  2. Solid masses
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7
Q

What are the questions to ask when evaluating a patient with a breast lump?

A
  • Personal history of breast cancer
  • prior breast biopsy (especially one indicating atypical hyperplasia)
  • risk factors for breast cancer
    • age
    • family history of breast cancer
    • age of menarche
    • age at first pregnancy
    • age at menopause
    • alcohol use
    • hormone replacement therapy
  • relationship with menstrual cycle
  • breast pain
  • nipple discharge
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8
Q

What percentage of women born in the United States will develop breast cancer at some time in their lives?

A

12.7% (1 in 8)

In Australia its 1 in 7

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9
Q

According to the National Cancer Institute’s Surveillance, Epidemiology, and End Results Program, what are the odds of developing breast cancer for 30-39 year olds?

A

1 in 233

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10
Q

What are the odds of developing breast cancer for 60-69 year olds?

A

1 in 27

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11
Q

What percentage of all breast cancers is associated with inherited genetic mutations?

A

5%-6% (most of the mutations involve BRCA1 and BRCA2)

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12
Q

According to the US Preventive Services Task Force, who should be offered testing for BRCA mutations among the non-Ashkenanzi women?

A
  • Anybody with two 1st-degree relatives with breast cancer (at least one diagnosed at age ≤50)
  • a combination of three or more 1st- or 2nd-degree relatives with breast cancer, regardless of age at diagnosis
  • a combination of both breast and ovarian cancer among 1st- and 2nd-degree relatives
  • a 1st-degree relative with bilateral breast cancer
  • a combination of two or more 1st- or 2nd-degree relatives with ovarian cancer, regardless of age at diagnosis
  • a 1st- or 2nd-degree relative with both breast and ovarian cancer at any age or
  • history of breast cancer in a male relative
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13
Q

According to the US Preventive Services Task Force, who should be offered testing for BRCA mutations among women of Ashekenazi Jewish descent?

A

Any 1st-degree relative (or two 2nd-degree relatives on the same side of the family) with breast or ovarian cancer

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14
Q

What are the options for breast and ovarian cancer surveillance and/or prophylaxis in patients with BRCA1 or BRCA2 mutations?

A

3 options can be consdered

  • increased surveillance
    • mammography
    • breast MRI
    • clinical/self-breast exams
    • transvaginal ultrasounds
    • serum CA-125 levels
  • chemoprevention
    • tamoxifen
    • oral contraception pills
  • riskreducing surgery
    • bilateral mastectom
    • bilateral salpingooporectomy
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15
Q

What is the role of ultrasound in evaluating breast lumps?

A
  • It distinguishes cysts from masse
  • determines whether a mammographically suspicious mass is amenable to ultrasound-guided biopsy
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16
Q

What are the types of breast cysts?

A
  • Simple cysts (benign)
  • complicated cysts (rarely malignant [0.4%])
  • complex cyst(contains cystic and solid components, 20-43% are cancerous)
17
Q

What are other benign causes of breast lumps?

A
  • Fibroadenomas
  • ductal hyperplasia without atypia
  • papilloma (can contain areas of atypia or ductal carcinoma in situ)
  • sclerosis adenosis
  • atypical hyperplasia (associated with increased risk of breast cancer)
18
Q

What are fibroadenomas?

A
  • Firm, painless, mobile masses that increase in size during pregnancy or with estrogen and regress after menopause
19
Q

What are the ways of obtaining biopsies of palpable or nonpalpable breast lesions?

A
  • Fine needle aspiration (for cystic lesions)
  • fine needle aspiration biopsy (for solid masses)
  • core needle biopsy (larger gauge needle compared to fine needle aspiration)
  • excisional biopsy
  • incisional biopsy (if the mass is too large to excise)
20
Q

What is the role of mammogram in evaluating a palpable breast lump?

A
  • Identifies other suspicious areas in either breast that might affect management
21
Q

What is the most common type of breast cancer?

A

Infiltrating ductal cancer (80%)

22
Q

The most common type of breast cancer is Infiltrating ductal cancer.

What are other types of breast cancer?

A
  • Infiltrating lobular
  • Paget disease
  • inflammatory carcinoma
23
Q

For which type of breast cancer is the overlying skin described as peau d’ orange (orange peel)?

A

Inflammatory carcinoma

24
Q

Which type of breast cancer is associated with nipple eczema and bloody nipple discharge?

A

Paget disease

25
Q

What is the difference between in situ and infiltrating carcinoma?

A

The tumor cells of in situ carcinomas remain within the ducts or lobules and do not invade the surrounding stroma.

26
Q

What percentage of breast masses are mammographically occult?

A

20% (suspicious masses should still be biopsied even after negative mammograms)

27
Q

Why are mammograms less useful in women under 35 years of age?

A

Their breast tissue is frequently too dense to adequately evaluate lumps