Exam 2 Flashcards
Functions of blood?
Transport, protection, and regulation
What does blood regulate?
Fluid balance, pH, and temperature
Normal blood pH?
7.35 to 7.45
Components of blood?
Plasma and blood cells
Components of plasma?
Proteins, clotting factors, mostly water
What are thrombocytes?
Platelets
Solids in plasma?
Nutrients, electrolytes, hormones, gases
What is the buffy coat?
White blood cells and platelets
Blood percentages?
55% plasma, 1% buffy coat, 45% erythrocytes
Major categories of plasma proteins?
Albumin, globulins, and fibrinogen
What is albumin responsible for?
Blood viscosity and osmolarity
What are globulins responsible for?
Antibodies
What is fibrinogen responsible for?
Precursor of fibrin threads
Formed elements of blood?
Erythrocytes, leukocytes, and thrombocytes
What are the different leukocytes?
Lymphocytes, monocytes, basophils, eosinophils, neutrophils
What is hemopoiesis?
AKA hematopoiesis, blood cell production
Where does hemopoiesis occur in adults?
Red bone marrow of axial skeleton, girdles, proximal epiphyses of humerus and femur
Where does hemopoiesis occur in children?
All red bone marrow
What are pluripotent stem cells?
PPSCs, they give rise to the formed elements
Steps of RBC maturation?
Erythroblasts multiply and synthesize hemoglobin, nucleus is discarded, and they then become erythrocytes
2 principal functions of erythrocytes?
Carry oxygen from lungs to tissues, and pick up carbon dioxide from tissues and bring to lungs
What is different about erythrocytes from average cells?
They lack mitochondria and are filled with hemoglobin for gas transport
Components of hemoglobin?
Globins, protein chains, and heme groups, nonproteins
What do heme groups do?
Bind oxygen to ferrous ion of iron
What is needed for RBC production?
Iron
What is ferritin?
Excess iron stored in the liver
What is transferrin?
Protein that binds to iron and transports it around the body
Average hematocrit in men and women?
Men - 42-52%
Women - 37-48%
Average hemoglobin concentration in men and women?
Men - 13-18 g/dL
Women - 12-16 g/dL
Ways to count erythrocytes and hemoglobin quantities?
Hematocrit, hemoglobin concentration, RBC count
How is erythrocyte homeostasis controlled?
Negative feedback
What happens to dying RBCs?
Macrophages engulf them in the spleen and liver
What happens to globins when RBCs are broken down?
They are turned into amino acids
What happens to heme groups when RBCs are broken down?
Iron is removed and saved
What happens to heme pigment when RBCs are broken down?
They get turned into bilirubin, which is yellow
What is polycythemia?
Excess RBCs
What is secondary polycythemia?
Excess RBCs from dehydration, physical conditioning, emphysema. Not as high as primary though
What can cause anemia?
Inadequate erythropoiesis or hemoglobin synthesis
What are hemorrhagic anemias?
Anemia caused by bleeding
What are hemolytic anemias?
Anemia caused by RBC destruction
Consequences of anemia?
Tissue hypoxia and necrosis, reduced blood osmolarity causing edema, low blood viscosity causing heart rate and pressure drop
What is sickle cell disease?
A hereditary hemoglobin defect caused by a recessive allele
Another name for antigens?
Agglutinogens
Another name for antibodies?
Agglutinins
What are antigens/agglutinogens?
Things on cells that determine your blood type. Antigen A and B
What are antibodies/agglutinins?
Things in the blood that attack antigens. Anti-A and anti-B
Universal recipient?
AB+, most rare
Universal donor?
O-, also the most common
What are D antigens?
They determine if you’re positive or not
What happens when Rh-negative mothers have Rh-positive babies?
First one causes the body to make anti-D antibodies, so the next baby will have their antigens be attacked
What can help stop formation of anti-D antibodies?
RhoGAM
How long are leukocytes in the bloodstream?
Only a few hours, then they migrate into connective tissue - lymph tissue
What do myeloblasts do?
Make neutrophils, eosinophils, and basophils
What do monoblasts do?
Make monocytes
Components of leukopoiesis?
Myeloblasts, monoblasts, and lymphoblasts
What do lymphoblasts do?
Make lymphocytes
Where do lymphocytes finish development?
Thymus
What do lymphocytes do?
Provide immunity that lasts decades
What do neutrophils do?
Fight bacterial infections
What do eosinophils do?
Fight parasitic infections
What do basophils do?
Secrete histamine, a vasodilator, and heparin, an anticoagulant
What are the granulocytes?
Neutrophils, eosinophils, and basophils
What are the agranulocytes?
Lymphocytes and monocytes
What do platelets do?
Secrete vasoconstrictors, procoagulants, chemicals to attract neutrophils, and growth factors
What is hemostasis?
Cessation of bleeding
What is coagulation of the extrinsic pathway?
Thromboplastin
What is coagulation of the intrinsic pathway?
Hageman factor
What is a thrombus?
A clot
What is an embolus?
Anything that can travel and block blood vessels
Go fill in the chapter 19 concept check
Done
Leukocytes from most to least numerous?
Neutrophils > lymphocytes > monocytes > eosinophils > basophils
What is needed for blood clotting?
Calcium and vitamin K
What is hypoplastic anemia?
Decline in erythropoiesis
What is aplastic anemia?
Cessation of erythropoiesis
Mechanisms of hemostasis?
Vascular spasm, platelet plug formation, and coagulation
What is hemophilia?
When you can’t make an effective clot so you bleed for longer
What is thrombocytopenia?
Abnormally low platelet count
What is fibrinolysis?
Breakdown of clots in blood
What is plasmin?
An enzyme that breaks up blood clots
How much of plasma is water?
90%
Blood pressure formula?
BP = cardiac output x systemic vascular resistance
What triggers under low oxygen levels?
Erythropoietin
How do babies develop jaundice?
Their RBCs have a shorter lifespan so more bilirubin accumulates
What determines SVR?
Vessel radius
Where is the heart?
In the mediastinum, between the lungs
Base of the heart?
At the top, wide
Apex of the heart?
Tapered, lower, left-pointing end of the heart
What circuit is the left side of the heart?
Systemic
What circuit is the right side of the heart?
Pulmonary
What is the systemic circuit?
Blood to the whole body
What is the pulmonary circuit?
Blood to the lungs
What is the pericardial sac/parietal pericardium?
Fibrous and serous layers with pericardial cavity between
What is pericarditis?
Painful inflammation of the pericardial membranes