Chronic Lymphocytic Leukemia Flashcards
1
Q
What is the first one investigation to confirm CLL?
A
Flow cytometry of peripheral blood
-> bone marrow biopsies are rarely carried out as flow cytometry can confirm diagnosis alone
2
Q
Which haemolytic anaemia is associated with CLL?
A
Warm autoimmune haemolytic anaemia
3
Q
How does CLL present?
A
Non-tender symmetrical lymphadenopathy
Hepatosplenomegaly
B symptoms – weight loss, night sweats and fever
Marrow failure is much less common
4
Q
Which lymphoma is most common following Richter’s transformation?
A
Diffuse large B cell lymphoma
5
Q
What indicates poor prognosis in CLL?
A
Anaemia and thrombocytopenia
