Cell regulation Flashcards
1
Q
Kinases are..
A
Proteins that phosphorylate other proteins
2
Q
Cyclins are…
A
Regulatory proteins that activate the kineses
3
Q
Cyclin dependent kinases are..
A
Phosphorylate target proteins that promote cell divison
4
Q
How does the cell regulation work?
A
- Cyclin binds to the CDK to activate the kinases
- Cyclin-CDK complexes phosphorylate the target proteins that lead to cell division
5
Q
When cyclin concentration is high the cell is in…
A
interphase
6
Q
When cyclin concentration is low the cell is in…
A
Mitosis
7
Q
M phase promoting factor (MPF)
A
- present in the cytoplasm of the M-phase
- Starts mitosis in all eukaryotes
- consist of protein kinases
- cyclin
8
Q
The M-cyclin complex
A
initiates events associated with mitosis
9
Q
The G1/S cyclin CDK complex
A
is active at the end of G1
10
Q
The S-cyclin complex
A
involves the initiation of DNA synthesize
11
Q
G1 checkpoint:
A
- cell size is good
- Nutrients is sufficient
- social signals are present
- DNA is undamaged
-p53
12
Q
G2 checkpoint:
A
- Chromosomes has successfully replicated
- DNA is undamaged
- activated MPF is present
13
Q
M-Phase checkpoint
A
- chromosomes have attached to the spindle
- chromosomes have properly segregated
- MPF is not there
