Histoplasma Capulatum-Historians Cave Flashcards
What are the common locations that Histoplasma Capsulatum is found
Bat or bird droppings (usually farms and caves) along the Mississippi and Ohio River Valleys
What is the mechanism of transmission for Histoplasma Capsulatum
Through the respiratory system
What are the histological findings for Histoplasma Capsulatum
Macrophages with intracellular oval bodies
What are the diagnostic methods for Histoplasma Capsulatum
KOH or rapid serum/urine antigen test
What is the relation of Histoplasma Capsulatum size to RBC and macrophages
Histoplasma Capsulatum is much smaller than RBCs, and multiple ovoid bodies would be seen in a macrophage
What is the life stage of Histoplasma Capsulatum
Dimorphism with yeast and mold
What is the common clinical presentation of Histoplasma Capsulatum
Pneumonia
erythema nodosum
Granulomas
Hepatosplenomegaly
What other infections does Histoplasma Capsulatum have the ability to mimic
Granulomas, which are typically seen in TB with calcified nodes and nodules in the hilar region
What population is commonly seen to have Histoplasma Capsulatum
Immunocompromised
Which organs tend to be disseminated with Histoplasma Capsulatum
Targets the reticuloendothelial system, so disseminates to liver and spleen(hepatosplenomegaly)
How is localized infections of Histoplasma Capsulatum treated
-Azoles
How are systemic infections of Histoplasma Capsulatum treated
Amphotericin B
