89 - Paraneoplastic Syndrome: Endocrinologic/Hematologic Flashcards
What is neoplastic syndrome?
Disorders that accompany benign or malignant tumors but are not directly related to mass effects or invasion.
What are the two most common types of tumors leading to neoplastic syndrome?
Carcinoid
SCLC
What is the most common reason for humoral hypercalcemia of malignancy (HHM)?
Increased secretion of PTHrP
What is the clinical manifestation of HHM (5)?
Hypercalcemia Fatigue Mental status changes Dehydration Nephrolithiasis
Diagnosing HHM (6):
An existing malignancy Recent hypercalcemia Hypophosphatemia Low PTH Metabolic alkalosis High PTHrP
How would you treat HHC?
Removal of excess calcium (hydration, diuretics…)
Ectopic vasopressin tumor associated SIADH is a _____
Paraneoplastic syndrome
Cushing’s syndrome caused by ectopic ACTH production is responsible to ____ of Cushing’s cases
10-20%
What are the common endocrine tumors that can cause neoplastic Cushing syndrome (4)?
SCLC
Carcinoids (bronchiole/thymus)
Islet cell tumors
Pheochromocytoma
The clinical presentation of Cushing’s syndrome caused by ectopic ACTH includes (6):
- Weight gain
- Hypokalemia
- HTN
- Metabolic alkalosis
- Glucose intolerance
- Psychosis
The diagnosis of Cushing’s syndrome caused by ectopic ACTH includes:
Increased urine cortisol levels
Increased serum ACTH levels
Non responsive dexamethasone test
Which cancers are related to paraneoplastic erythrocytosis?
Renal cancer
Hepatocarcinoma
Cerebellar hemangioblastomas
Which cancers are related to paraneoplastic granulocytosis ?
Lung cancer GI cancer Breast cancer Ovarian cancer Hodgkin's disease
Which cancers are related to paraneoplastic thrombocytosis?
Lung cancer GI cancer Breast cancer Ovarian cancer Lymphoma
Which cancers are related to paraneoplastic eosinophilia?
Lymphoma
Leukemia
Lung cancer
