105 - Hodgkin's Lymphoma Flashcards
HL is defined as lymphoma of __ __ cells. It makes up to _% of lymphomas. High cure rate- _%
adult
B
10
85
HL is more common in __ __. Typical age at diagnosis is divided to two peaks- __ and __
white
men
20
80`
HL is classified into 4 types:
nodular sclerosis
lymphocyte rich
mixed cellularity
lymphocyte depleted
__ and __ make 95% of HL. Young patients usually have __, while HIV/elders/3rd world have more __
nodular sclerosis
mixed cellularity
nodular sclerosis
mixed cellularity
The presence of __ cells is enough to diagnose the disease.
Reed-Sternberg
Reed Sternberg cells are __ with a lot of __, __/__ nuclei. They are positive for __ and rarely express __/__. 85% will express __, and 100% express __
large cytoplasm bilobed/multi PAX5 CD19/20 CD15 CD30
Most patients with HL will present with palpable __. It will be __, usually in the __/__/__. 50% of patients will present with __ lymphadenopathy.
lymphadenopathy
unpainful
neck/axilla/supraclavicular
mediastinal
30% HL patients will show __symptoms, and __ (Pel–Ebstein fever). Rare presentation may also include lymph node pain when consuming __
B
FUO
alcohol
In order to diagnose HL- perform __ and look for tumor mass of __ cell origin with __ infiltration.
biopsy
B
inflammatory
It is important to look for comorbidities when diagnosing HL, especially __ and __, due to the treatment’s __
lung
CHF
S/E
DDx for HL includes: 4
NHL
mononucleosis
infectious process
adenopathy due to phenytoin (anti seizure)
HL staging is done with __. It is more accurate in locating __ involvement.
PET CT
BM
HL early disease early disease is- __, late disease is -__
1-2
3-4
HL stage 1:
Involvement of __ lymph node region or lymphoid structure
1
HL stage 2:
Involvement of __ lymph node region or lymphoid structure on the same side of the __
> 1
diaphragm