360 - Sarcoidosis Flashcards

1
Q

Sarcoidosis is a non ____ caseating granulomatous disease

A

caseating

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2
Q

The presence of granulomas is not specific for the diagnosis of sarcoidosis, we must rule out other causes such as: (4)

A

TB
fungal infection
malignancy
beryllium

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3
Q

The most common organs to be affected are the ___, but other organs such as the ___, ___, and ___ may be affected

A

lung
liver
skin
eye

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4
Q

___% of patients go into remission while the other develop a chronic disease lasting years

A

50

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5
Q

The etiology is ___ but, but in most cases it is probably due to environmental/infectious factor

A

unknown

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6
Q

more ___ than south, more ___ than white, more ___ than men, ___ and old (median age- __).

A
north
black
women
young
55
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7
Q

BAL will show an ___ response with a flow of __ cells and accumulation of activated ___

A

inflammatory
T
monocytes

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8
Q

The __ cells are crucial to the pathogenesis of the disease

A

T

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9
Q

Lofgren’s syndrome is characterized by ___ and ___ in CXr

A

erythema nodosum

hilar adenopathy

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10
Q

Lofgren’s syndrome has a ___ prognosis with over __% recovery within 2 years

A

better

95

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11
Q

The most common clinical sign is ___ and ___. Other symptoms may include ___ symptoms, ___ , and ___.

A
cough
dyspnea
B
ocular
cutaneous
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12
Q

___ is not a good imaging tool to diagnose sarcoidosis. Use ___.

A

CT

CXr

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13
Q

What is the CXr staging system?

A

Scadding’s score

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14
Q

Scadding’s score stage 1

A

Hilar adenopathy + right side paratracheal involvement

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15
Q

Scadding’s score stage 2

A

combination of adenopathy + infiltrates

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16
Q

Scadding’s score stage 3

A

infiltrates only

17
Q

Scadding’s score stage 4

A

fibrosis

18
Q

The infiltrates are usually found in the ___ lobes

A

upper

19
Q

Cutaneous involvement is in ___ of the patients

A

1/3

20
Q

What are the common cutaneous signs? (5)

A
erythema nodosum
maculopapular lesions
hyopo/hyper pigmentation
keloid formation
sub cutaneous nodules
21
Q

The commonly involved cutaneous areas are: (2)

A
nose bridge
lupus pernio (under the eyes and cheeks)
22
Q

The common ocular symptoms are: (3)

A

anterior uveitis
posterior retinitis
pars planitis

23
Q

The most common hepatic involvement is increase in liver function (3)

A

ALKP
transaminase
bilirubin

24
Q

Most hepatic symptoms are due to ____ but some are caused by ___ leading to ____ (ascites and varices)

A

hepatomegaly
cholestasis
biliary HTN

25
Q

Diagnosis is made through ___ showing ___ of non caseating type, and with other causes been ruled out

A

biopsy

granuloma

26
Q

___ is the drug of choice for initial treatment

A

GC

27
Q

____ is better for cutaneous symptoms

A

hydroxychloroquine

28
Q

Cytotoxic drugs are also useful (4)

A

MTX
azathioprine
cyclophosphamide
mycophenolate