189 - Epstein-Barr Virus Infections- Infectious mononucleosis (EBV)

Question 1

EBV causes ___

Answer 1

Infectious mononucleosis

Question 2

_ cells play a major role in defending against EBV

Answer 2

T

Question 3

Which cancer types are associated with EBV?

Answer 3

nasopharyngeal
Burkitt's lymphoma
Hodgkin's lymphoma
Gastric carcinoma
B cell lymphoma (in immunocompromised)

Question 4

EBV has an incubation period of - weeks followed by a prodrome of - weeks.

Answer 4

4-6

1-2

Question 5

EBV prodrome includes the triad of:

They will last for - weeks.

Answer 5

fever
tonsillar pharyngitis
lymphadenopathy
2-3

Question 6

Oral hairy leukoplakia can be the primary presentation of EBV in __ patients

Answer 6

HIV

Question 7

The lab results typical in EBV include: 5

Answer 7

leukocytosis (10-20 K) + atypical lymphocytes
liver function disorder + bilirubin increase
SMA/ANA/RF/cryoglobulin

Question 8

Heterophile test is designed to diagnose __ in children and adults.

Answer 8

IM (infectious mononucleosis)

Question 9

Heterophile test requires titer > __ + IM symptoms. 40% will be positive in the __ week, while 80-90% by the __ week.

Answer 9

40
first
third

Question 10

Serological test is recommended for patients with ___

Answer 10

negative heterophile antibodies

Question 11

In the serologic test- look for __ Ab, which will be positive in the first __ months.

Answer 11

IgM

2-3

Question 12

EBNA seroconversion will become positive - weeks post symptoms.

Answer 12

3-6

Question 13

CNS involvement (__/__) is more typical in the first __ weeks.

Answer 13

meningitis/encephalitis

2

Question 14

Name an hematologic disorder which result from a complication of EBV:

Answer 14

Autoimmune hemolytic anemia

Question 15

What will autoimmune hemolytic anemia result in? 4

Answer 15

RBC aplasia
Granulocytopenia
thrombocytopenia
pancytopenia

Question 16

Splenic __ may occur in 0.5% of cases.

Answer 16

rapture

Question 17

Which recessive genetic disease may result in death if the patient gets infected with EBV?

Answer 17

X linked lymphoproliferative disease

Question 18

What does IM treatment involve? 3

Answer 18

Rest+ avoid physical activity for 1 month (to prevent splenic rapture)
steroids (not in normal patients)
acyclovir (not in normal patients)

Question 19

When should steroids be given to a EBV patients? 3

Answer 19

prevention of airway obstruction in severe tonsillar hypertrophy
AIHA
severe thrombocytopenia

Question 20

Which EBV patients should be treated with acyclovir?

Answer 20

hairy leukopenia

active chronic EBV (not acute IM)