310 - Tubulointerstitial Diseases of the Kidneys Flashcards
We differentiate tubulointerstitial disease into __ and __.
acute
chronic
TIN= ___
tubulointerstitial nephritis
Acute TIN is defined as aggressive ___ infiltration leading to tissue __, damage to __ cells and flow, or obstruction by __/__/__.
inflammatory
edema
tubular
casts/crystals/cell debris
Clinical symptoms of acute TIN include __ due to capsular stretching.
flank pain
Acute TIN urine will contain __ and cellular __.
leukocytes
casts
Chronic TIN will cause __ due to difficulties to __ it.
polyuria
concentrate
Chronic TIN may lead to __ syndrome: 5
Fanconi glycosuria Phosphaturia Amino acids in urine hypokalemia RTA type II (due to HCO3 urine excretion)
Chronic TIN may lead to RTA type __ with non-AG __ acidosis and hyper__ due to __ production.
4
metabolic
kalemia
ammonia
Chronic TIN may present with advanced __ and __ (rarely >2 gr/day).
azotemia
albuminuria
Chronic TIN US may present increased __ and __ (IS __)
echogenic
scarring
fibrosis
Now days, acute TIN is usually caused by drug __. Other reasons may include: 3
allergy
infection
systemic AI disease
obstruction
What are the main drugs causing allergic TIN? 7
anti TB fluoroquinolones sulfonamides Beta lactam NSAID diuretics alopurinol
The classic presentation of allergic TIN includes:4
fever
rash
peripheral eosinophilia
oliguric renal insufficiency
Allergic TIN usually starts - days after __ Abx
7-10
B lactam
The common presentation of allergic TIN includes increased __ in serum or __ symptoms.
Cr
AKI