350 - Antiphospholipid Syndrome Flashcards
What are the common characteristics of APS? (2)
thrombosis (arterial/venous)
pregnancy complications
When will APS be considered secondary?
when appear with other AI disease (SLE…)
Define catastrophic APS:
rapidly progressive life-threatening thromboembolic disease which involves >= 3 organs
APS is a syndrome of ___ (thrombophilia), mediated by ___
hypercoagulability
auto Ab
Which disease may be false positively diagnosed together with APS?
syphilis
To diagnose APS we need 1 ___ sign and 1 ___ sign together with the absent of other reasons for a hypercoagulability state
clinical
lab
Name two clinical signs for APS
Thrombosis (venous/arterial)
Obstetric problem
What kind of obstetric problems are relevant for APS diagnosis? (3)
death of a healthy embryo within the first 10 weeks
severe preeclampsia leading to early birth
>=3 abortions (<10 weeks)
List 3 lab characteristics for APS diagnosis
lupus anticoagulant
anticardiolipin
anti beta2GPI
DVT (__%) occurs mainly in the lower limbs leading to PE (__%), livedo reticularis (__%)
39
15
24
Thrombosis in the ____ leads to pulmonary hypertension and thrombosis of the inferior vena cava and to ___ syndrome
pulmonary arteries
Budd-Chiari
What are the 4 most common arterial thrombi in APS?___(20%), ___(14%), ___(11%), ___(10%)
stroke
Liebman Sacks (cardiac valve injury)
TIA
MI
The most common neurological symptom of APS is __ (20%)
migraine
The most common hematological signs of APS are__ (30%) and ___ (10%)
thrombocytopenia
AIHA
Treating APS after the first episode requires life long treatment of ____. INR should be kept between __-__. This could be the sole therapy or in combination with ___
warfarin (Coumadin)
2.5-3.5
aspirin