130 - Urinary Tract Infection, Pyelonephritis, and Prostatitis Flashcards

1
Q

UTI can be __ or __

A

uncomplicated (cystitis, pyelonephritis in non pregnant)

complicated - all the other cases

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2
Q

What are the risk factors for acute cystitis? 7

A
diaphragm
high frequency intercourse
previous UTI
diabetes
incontinence 
new sexual partner
maternal history
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3
Q

In diabetic patients long term use of __ and __ increase the risk for UTI

A

insulin

SGLT2

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4
Q

UTI in men is more common when >_, due to __ hypertrophy. __ reduce the risk as well

A

45
prostate
circumcision

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5
Q

The main pathogens causing uncomplicated UTI and pyelonephritis are: 6

A
E.coli
staph saprophyticus
enterococcus
proteus 
Klebsiella
Citrobacter
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6
Q

The main pathogens causing complicated UTI and pyelonephritis are: 6

A
E.coli
proteus 
Klebsiella
pseudomonas aeruginosa 
actinobacteria 
Citrobacter
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7
Q

What are the classic symptoms of cystitis?

A

dysuria
urgency and frequency
nocturia

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8
Q

What are the classic symptoms of pyelonephritis?

A

low fever

lower back/rib pain

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9
Q

Severe pyelonephritis will present with: 5

A
high fever
nausea
vomiting
flank pain
papillary necrosis
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10
Q

Xanthogranulomatous pyelonephritis=__

A

combination of chronic infection + urinary obstruction - resulting in pus destroying the kidney parenchyma

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11
Q

only certain strains of __ will transform __ into nitrite

A

Enterobacteriaceae

nitrate

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12
Q

Uncomplicated cystitis with unspecific symptoms requires __. If __ or __ are + -> __treatment. If it is negative: __ or__

A
urine stick 
nitrite
leukocytes 
empiric 
culture
follow up
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13
Q

Men with cystitis should be tested with __. If there is fever as well- __/__

A

culture

US/CT

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14
Q

Treating uncomplicated cystitis in women can be done with __/__/__ - they will have a minimal influence in the flora, while __/__/__ will have a more significant effect.

A
nitrofurantoin
pivmecillinam
fosfomycin
quinolones 
TMP-SMX
ampicillin
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15
Q

Fosfomycin can be given in a __ dose

A

single

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16
Q

What will you use to treat pseudomonas UTI?

A

fluoroquinolones (ciprofloxacin/levofloxacin)

17
Q

What are the downsides of using fluoroquinolones to treat UTI?

A

increasing resistance
Achilles tendon rapture
irreversible neuropathy

18
Q

What is the first line of treatment for pyelonephritis? mention 4 other recommended treatments

A

fluoroquinolones
TMX-SMX (if the pathogen is sensitive) + ceftriaxone (if the sensitiveness is unknown)
carbapenem
cephalosporine

19
Q

If the patient has recqurent pyelonephritis or resistant strain/previous procedure in urinary system treat with-__

A

carbapenem

20
Q

What is the drugs of choice for pyelonephritis during pregnancy? 3

A

cephalosporines
ampicillin
nitrofurantoin

21
Q

Women with ASB should be treated for - days, pregnant + pyelonephritis should receive IV __ +/- __

A

beta lactam

aminoglycoside

22
Q

When treating pyelonephritis, which drug should be avoided during the 1st trimester and near the time of birth? why?

A

sulfonamides

cause cartilage damage to the embryo

23
Q

What is the drug of choice for pyelonephritis in men?

A

fluoroquinolones or TMX-SMX

24
Q

What is the recommended treatment for xanthogranulomatous complicated UTI?

A

nephrectomy

25
Q

What is the recommended treatment for emphysematous complicated UTI?

A

percutaneous drainage followed by nephrectomy if needed

26
Q

What is the recommended treatment for papillary necrosis complicated UTI?

A

open the obstruction

27
Q

Which patients must be treated for ASB? 4

A

pregnant
prior to UG surgery
neutropenic
post kidney transplantation

28
Q

CAUTI=__

A

catheter associated UTI

29
Q

What is one of the most important steps in treating CAUTI?

A

replace the catheter + Abx

30
Q

What is the first line of treatment for candiduria?

A

in asymptomatic- remove catheter
if symptomatic/high risk/prior to UG surgery-fluconazole for 7-14 days.
if the strain is resistant- amphotericin B/flucytosine