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vasculitis Flashcards

1
Q

vasculitis is

A

inflammation of blood vessels

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2
Q

__ are seen in blood vessel walls in vasculitis

A

leukocytes

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3
Q

typical inflammation sxs

A

fever
myalgias
arthralgias
fatigue

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4
Q

organ/disease specific sxs in vasculitis due to

A

vessel lumen narrows or occludes from inflammation

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5
Q

large vessel vasculitis includes

A

temporal arteritis
takayasu’s arteritis

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6
Q

medium vessel vasculitis includes

A

polyarteritis nodosa
kawasaki disease
buerger’s disease

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7
Q

small vessel vasculitis includes

A

churg-strauss
Wegener’s granulomatosis
microscopic polyangitis
henoch-schonlein purpura

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8
Q

purpura

A

red-purple skin lesions

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9
Q

palpable purpura is due to

A

extravagtion of blood into skin (code for vasculitis)

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10
Q

non palpable purpura is usually

A

noninflammatory

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11
Q

vasculitis treatment

A

steroids or cyclophosphamide

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12
Q

features of temporal arteritis

A

elderly female
HA

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13
Q

features of takayasus

A

again female
pulseless

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14
Q

features Kawasaki disease

A

asian child
red rash
strawberry tongue

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15
Q

features buergers disease

A

smokers hands

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16
Q

features of polyarteritis nodosa

A

hep b

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17
Q

features of henoch-schonlein purpura

A

child
URI
melena

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18
Q

features of charge strauss

A

asthma
eosinophils
p-ANCA

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19
Q

features of Wegener’s granulomatosis

A

sinus
kidneys
lungs
c-ANCA

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20
Q

microscopic polyangitis

A

kidneys
lungs
p-ANCA

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21
Q

temporal arteritis narrowing of

A

temporal artery system

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22
Q

sxs of temporal arteritis

A

HA
jaw claudication

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23
Q

if temporal arteritis is not treated it can lead to

A

blindness

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24
Q

diagnosis of temporal arteritis

A

biopsy of temporal artery (granulomas)

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25
Q

treat temporal arteritis with

A

high dose steroids

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26
Q

takayasu’s arteritis is due to

A

granulomatous thickening of aortic arch and branches

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27
Q

takayasu’s arteritis classical sxs

A

weak pulses one arm

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28
Q

kawasaki disease is due to

A

narrowing of proximal great vessels

29
Q

classic involvement of Kawasaki

A

skin
lips
tongue

30
Q

sxs of Kawasaki

A

red rash
strawberry tongue

31
Q

feared complication of Kawasaki

A

coronary aneurysms (MI)

32
Q

treatment of Kawasaki

A

IV immunoglobulin and aspirin

33
Q

scarlet fever

A

fever
sore throat***
sandpaper skin
strawberry skin

34
Q

Reye’s syndrome characterized by

A

encephalopathy
liver failure
fatty infiltration

35
Q

Reye’s syndrome sxs

A

vomiting
confusion
seizures
coma

36
Q

Reye’s syndrome often follows

A

viral illness

37
Q

Reye’s syndrome caused by

A

diffuse mitochondrial insult

38
Q

Reye’s syndrome associated with

A

aspirin use in children

39
Q

buergers disease seen in

A

male smokers

40
Q

burgers disease is due to

A

poor blood flow to hands/feet

41
Q

treatment for buerger’s disease

A

smoking cessation

42
Q

polyarteritis nodosa due to

A

immune complex mediated

43
Q

polyarteritis nodosa is what type of hypersensitivity

A

type III

44
Q

polyarteritis nodosa sxs

A

motor/sensory deficits
nodules/purpura on skin
renal failure

45
Q

polyarteritis classic case

A

hep B+
nerve deficits
skin nodules
purpura
renal failure

46
Q

henoch-schonlein purpura is the mc

A

childhood systemic vasculitis

47
Q

henoch-schonlein purpura is associated with

A

IgA

48
Q

henoch-schonlein purpura sxs

A

palpable purpura on buttocks/legs
abd pain, melena
nephritis

49
Q

henoch-schonlein purpura classic cause

A

child with recent URI
palpable purpura
melena

50
Q

__ is best test for henoch-schonlein

A

tissue biopsy

51
Q

ANCA diseases

A

churg-strauss syndrome
wegener’s granulomatosis
microscopic polyangiitis

52
Q

ANCA all have

A

pulmonary & renal involvement

53
Q

c-ANCA seen in

A

wegener’s

54
Q

p-ANCA seen in

A

charge-strauss
microscopic polyangitis

55
Q

churg-strauss sxs

A

asthma
sinusitis
neuropathy

56
Q

__ is seen in charge Strauss

A

eosinophilia

57
Q

wegener’s granulomatosis ses

A

sinusitis, otitis media, hemoptysis

58
Q

renal sxs of wageners

A

hematuria
red cell casts

59
Q

__ on biopsy of wegener’s

A

granulomas

60
Q

microscopic polyangitis sxs

A

hemoptysis, kidney failure, purport

61
Q

microscopic polyangitis is just like wegeners except

A

no sinusitis
P-anca no C-anca
no granulomas

62
Q

good pastures syndrome due to

A

antibody to collagen

63
Q

sxs of good pasture syndrome

A

hemoptysis & nephritic syndrome

64
Q

classic cause of good pastures

A

young male
hemoptysis
hematuria

65
Q

biopsy of temporal arteritis reveals

A

multinucleated giant cells

66
Q

patients with polyarteritis nodosa present with

A

tender skin nodules

67
Q

fibrinoid necrosis is associated with

A

polyarteritis nodosa

68
Q

c-ANCA are antibodies against

A

proteinase-3

69
Q

p-ANCA are antibodies against

A

myeloperoxidase

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