t cells Flashcards
T cells only recognize
peptides
T cells only recognize antigen when
“presented”
T cells only react to antigen when placed on
“self” MHC
CD4 T cell role
produce cytokines, activate other cells, direct immune response
CD8 T cell role
kill virus infected cells
CD4 T cells are activated by
antigen presenting cells, MHC class II
B7 protein on APC binds __ on CD4 T cells
CD28
CD4 T cell activation stimulates
B cells, CD8 T cells, macrophages
Th1 cells activate
CD8 cells & macrophages
Th1 cells promote
specific IgG subclasses
__ from macrophages drive Th1 production
IL-12
Th2 cells activate
B cells to produce antibodies
Th1 cytokines
IL-2, INF gamma
IL-2 role
T cell growth factor
INF gamma role
activates Th1 & macrophages
Th2 cytokines
IL-4, IL-5, IL-10
IL-4 role
promotes IgE production
IL-5 role
promotes IgA production, activates eosinophils
IL-10 role
inhibits Th1, anti inflammatory
Th1 is import for
many intracellular infections
Crohn’s disease
TH1 mediated
ulcerative colitis
Th2 mediated
IL-12 receptor deficiency
cannot trigger differentiation of Th1
leads to decreased macrophages
INF gamma deficiency
INF gamma not effective, need cont anti microbial therapy
MCH class 1 binds
TCR and CD8
CD8 function
insert performs & granzymes & produce fas ligand
regulatory T cell role
suppress CD4 & CD8
reg T cell produce what cytokines
IL-10, TNF beta
classical marker of t reg cells
CD25
Th17 is important for
mucosal immunity
super antigens cause
toxic shock syndrome
for a t cell to survive it must
bind to self MHC and not bind in presence of self antigens
where does positive selection take place
thymus cortex
where does negative selection take place
thymus medulla
genes responsible for expression of self antigens
AIRE genes
