nonhodgkin lymphoma Flashcards
characteristics of nonhodgkin lymphomas
multiple sites
noncontiguous spread
extranodal involvements
wanderer’s ring
lymphoid tissue in the pharynx, often the site of non-hodgkin lymphoma
outer portion of lymph nodes
cortex
diffuse large B cell lymphoma markers
CD19, CD20
diffuse large B cell lymphoma occurs in
HIV
monoclonal CD20 antibody used to treat diffuse large B cell lymphoma
rituximab
follicular lymphoma genetic hallmark
t(14;18)
t(14;18) in follicular lymphoma causes
over expression of BCL2 (antagonist of apoptosis)
follicular lymphoma course
waxes/wanes for years
reactive lymphoma (LAD) due to
somatic hypermutation of B cells
reactive lymphoma causes
apoptosis of many B cells activating macrophages
mantle cell lymphoma marker
CD5 (B cells)
mantle cell genetics
t(11;14)
t(11;14) in mantle cell lymphoma causes
over expression of cyclin D1 promoting the cell cycle transition from G1 to S
