chronic leukemia

Question 1

characteristics of chronic leukemias

Answer 1

slower onset
malignant cells are more mature

Question 2

chronic myelogenous leukemia is due to dysregulated production of

Answer 2

granulocytes

Question 3

peripheral blood in chronic myeloid leukemia shows increased

Answer 3

basophils

Question 4

3 phases of chronic myeloid leukemia

Answer 4

chronic, accelerated, blast

Question 5

left shift (leukemoid reaction)

Answer 5

normal response to infection

Question 6

LAP (leukocyte alkaline phosphatase) in leukemoid reaction

Answer 6

high (low in CML)

Question 7

genetic hallmark of chronic myeloid leukemia

Answer 7

philadelphia chromosome (9;22)

Question 8

philadelphia chromosome causes what fusion

Answer 8

BCR-ABL

Question 9

BCR-ABL fusion causes synthesis of

Answer 9

tyrosine kinase protein

Question 10

chronic lymphocytic leukemia markers

Answer 10

CD5+ & CD20+ B cells

Question 11

signs of chronic lymphocytic leukemia

Answer 11

lymphadenopathy, splenomegaly

Question 12

smear of chronic lymphocytic leukemia

Answer 12

smudge cells (peripheral lymphocytes are fragile)

Question 13

chronic lymphocytic leukemia patients have increased susceptibility to

Answer 13

bacterial infections (due to B cell disruption)

Question 14

chronić lymphocytic leukemia may transform into

Answer 14

diffuse large B cell lymphoma

Question 15

hairy cell leukemia markers

Answer 15

CD103 (B cells)

Question 16

3 unique features of hairy cell leukemia

Answer 16

1. massive splenomegaly
2. dry tap
3. pos stain for tartrate resistant acid phosphatase

Question 17

presenting feature of hairy cell leukemia is often

Answer 17

abd pain