platelet activation Flashcards
1
Q
platelets are derived from
A
megakaryocytic
2
Q
production of platelets is regulated by
A
thrombopoietin
3
Q
platelets aid in
A
homeostasis after vascular injury
4
Q
platelets activate due to
A
endothelial injury & stimuli from other activated platelets
5
Q
3 actions of platelets
A
- adhesion
- aggregation
- secretion
6
Q
von willebrand factor is synthesized by
A
megakaryocytes
7
Q
vWF is stored in
A
weibel-palade bodies & alpha granules of platelets
8
Q
vWF is released on
A
vascular injury
9
Q
roles of vWF in hemostasis
A
- carrier protein for factor VIII
- binds platelets
10
Q
vascular damage causes
A
exposure of collagen
11
Q
sub endothelial collagen binds
A
vWF
12
Q
vWF bind __ on platelets
A
GP1B
13
Q
first step in forming platelet plug
A
vWF binding GP1B on platelets
14
Q
platelet aggregation is mediated by
A
GPIIa/IIIa receptor
15
Q
platelet activation causes
A
GPIIb/IIIa to change conformation and becomes capable of binding
