innate immunology

Question 1

cytokines

Answer 1

cell signaling proteins

Question 2

chemokines role

Answer 2

chemotaxis

Question 3

the innate immune sys recognizes molecules that are foreign through

Answer 3

pathogen associated molecular patterns (PAMPS)

Question 4

PAMPS are recognized by

Answer 4

toll like receptors

Question 5

endotoxin LPS binds to LPS binding factor in plasma which binds to

Answer 5

CD14 on macrophages

Question 6

binding of LPS to Cd14 triggers TL4 to release

Answer 6

IL-1, IL-6, IL-8, TNF alpha

Question 7

peptidoglycan is recognized by binding

Answer 7

NOD receptors

Question 8

mannose binds mannose binding lectin molecules and __ is activated

Answer 8

complement

Question 9

3 functions of macrophages

Answer 9

phagocytosis, produces cytokines, present antigens

Question 10

major activator of macrophages

Answer 10

INF gamma

Question 11

TB infects cells by

Answer 11

modifying phagosome so it cannot fuse with lysosome

Question 12

chediak hibachi infects cells by

Answer 12

failure of lysosome to fuse with phagosome

Question 13

role of IL-1 and TNF alpha

Answer 13

allows neutrophils to enter

Question 14

IL-1

Answer 14

fever

Question 15

TNF alpha

Answer 15

vascular leak, intravascular coagulation

Question 16

IL-6

Answer 16

fever, stimulates acute phase reactants

Question 17

IL-8

Answer 17

attracts neutrophils

Question 18

IL-12

Answer 18

promotes T helper 1 development

Question 19

rolling phase

Answer 19

selections bind e/p selection

Question 20

crawling phase

Answer 20

integrins bind ICAM

Question 21

transmigration phase

Answer 21

neutrophils bind PECAM1

Question 22

small neutrophil granules

Answer 22

alkaline phosphatase, fuse w phago and kill pathogens

Question 23

large neutrophil granules

Answer 23

acid phosphatase, fuse with phago

Question 24

acute phase reactants

Answer 24

produced in liver, increase inflammation

Question 25

eosinophils are activated by

Answer 25

IgE

Question 26

what causes degranulation of mast cells/basophils

Answer 26

cross linking of IgG

Question 27

role of NKC

Answer 27

kill human cells infected by virus, produce IFN gamma to activate macrophages

Question 28

MHC I

Answer 28

present antigens to CD8

Question 29

dendritic cell role.

Answer 29

antigen presentation, migrate to lymph nodes and activate T cells

Question 30

antibody dependent cellular toxicity of NKC

Answer 30

IgG bings pathogen infected cells CD16 and NKC binds the Fc portion of IgG

Question 31

macrophages release

Answer 31

IL-1 and TNF alpha