innate immunology Flashcards
cytokines
cell signaling proteins
chemokines role
chemotaxis
the innate immune sys recognizes molecules that are foreign through
pathogen associated molecular patterns (PAMPS)
PAMPS are recognized by
toll like receptors
endotoxin LPS binds to LPS binding factor in plasma which binds to
CD14 on macrophages
binding of LPS to Cd14 triggers TL4 to release
IL-1, IL-6, IL-8, TNF alpha
peptidoglycan is recognized by binding
NOD receptors
mannose binds mannose binding lectin molecules and __ is activated
complement
3 functions of macrophages
phagocytosis, produces cytokines, present antigens
major activator of macrophages
INF gamma
TB infects cells by
modifying phagosome so it cannot fuse with lysosome
chediak hibachi infects cells by
failure of lysosome to fuse with phagosome
role of IL-1 and TNF alpha
allows neutrophils to enter
IL-1
fever
TNF alpha
vascular leak, intravascular coagulation
IL-6
fever, stimulates acute phase reactants
IL-8
attracts neutrophils
IL-12
promotes T helper 1 development
rolling phase
selections bind e/p selection
crawling phase
integrins bind ICAM
transmigration phase
neutrophils bind PECAM1
small neutrophil granules
alkaline phosphatase, fuse w phago and kill pathogens
large neutrophil granules
acid phosphatase, fuse with phago
acute phase reactants
produced in liver, increase inflammation
eosinophils are activated by
IgE
what causes degranulation of mast cells/basophils
cross linking of IgG
role of NKC
kill human cells infected by virus, produce IFN gamma to activate macrophages
MHC I
present antigens to CD8
dendritic cell role.
antigen presentation, migrate to lymph nodes and activate T cells
antibody dependent cellular toxicity of NKC
IgG bings pathogen infected cells CD16 and NKC binds the Fc portion of IgG
macrophages release
IL-1 and TNF alpha
