innate immunology Flashcards

1
Q

cytokines

A

cell signaling proteins

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2
Q

chemokines role

A

chemotaxis

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3
Q

the innate immune sys recognizes molecules that are foreign through

A

pathogen associated molecular patterns (PAMPS)

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4
Q

PAMPS are recognized by

A

toll like receptors

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5
Q

endotoxin LPS binds to LPS binding factor in plasma which binds to

A

CD14 on macrophages

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6
Q

binding of LPS to Cd14 triggers TL4 to release

A

IL-1, IL-6, IL-8, TNF alpha

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7
Q

peptidoglycan is recognized by binding

A

NOD receptors

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8
Q

mannose binds mannose binding lectin molecules and __ is activated

A

complement

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9
Q

3 functions of macrophages

A

phagocytosis, produces cytokines, present antigens

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10
Q

major activator of macrophages

A

INF gamma

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11
Q

TB infects cells by

A

modifying phagosome so it cannot fuse with lysosome

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12
Q

chediak hibachi infects cells by

A

failure of lysosome to fuse with phagosome

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13
Q

role of IL-1 and TNF alpha

A

allows neutrophils to enter

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14
Q

IL-1

A

fever

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15
Q

TNF alpha

A

vascular leak, intravascular coagulation

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16
Q

IL-6

A

fever, stimulates acute phase reactants

17
Q

IL-8

A

attracts neutrophils

18
Q

IL-12

A

promotes T helper 1 development

19
Q

rolling phase

A

selections bind e/p selection

20
Q

crawling phase

A

integrins bind ICAM

21
Q

transmigration phase

A

neutrophils bind PECAM1

22
Q

small neutrophil granules

A

alkaline phosphatase, fuse w phago and kill pathogens

23
Q

large neutrophil granules

A

acid phosphatase, fuse with phago

24
Q

acute phase reactants

A

produced in liver, increase inflammation

25
eosinophils are activated by
IgE
26
what causes degranulation of mast cells/basophils
cross linking of IgG
27
role of NKC
kill human cells infected by virus, produce IFN gamma to activate macrophages
28
MHC I
present antigens to CD8
29
dendritic cell role.
antigen presentation, migrate to lymph nodes and activate T cells
30
antibody dependent cellular toxicity of NKC
IgG bings pathogen infected cells CD16 and NKC binds the Fc portion of IgG
31
macrophages release
IL-1 and TNF alpha