scleroderma

Question 1

in scleroderma endothelial cell damage results in

Answer 1

fibroblast activation & excess collagen deposition

Question 2

diffuse scleroderma

Answer 2

skin thickening
raynauds phenomenon
early visceral organ involvement

Question 3

pulmonary disease in scleroderma

Answer 3

pulmonary hypertension
interstitial lung disease

Question 4

scleroderma renal crisis acute worsening of

Answer 4

renal function

Question 5

scleroderma renal crisis responds to

Answer 5

ACE inhibitors

Question 6

limited scleroderma sxs

Answer 6

CREST
calcinosis
raynauds
esophageal dysmotility
sclerodactyly
telangiectasia

Question 7

in calcinosis deposits in subcutaneous tissue causing

Answer 7

bumps on elbows, knees, & fingers

Question 8

in calcinosis skin can break and leak

Answer 8

white liquid fluid

Question 9

X-rays of hands in calcinosis show

Answer 9

soft tissue calcifications

Question 10

esophageal dysmotility sxs

Answer 10

LES hypotonia, difficulty swallowing

Question 11

sclerodactylyl is caused by

Answer 11

fibrosis of skin of hands

Question 12

sclerodactylyl sxs

Answer 12

skiny skin
thickened skin
loss of wrinkles

Question 13

telangiectasias is due to

Answer 13

dilated capillaries

Question 14

with limited scleroderma main risk is

Answer 14

pulmonary disease

Question 15

antibodies associated with diffuse dz

Answer 15

anti-topoisomerase 1
anti-RNA polymerase III

Question 16

antibody associated with limited dz

Answer 16

anti-centromere

Question 17

primary biliary cirrhosis sxs

Answer 17

jaundice, fatigue, itching (associated with scleroderma)

Question 18

which antibody is associated with increased risk of renal crisis

Answer 18

anti-RNA polymerase III