b cells

Question 1

once a B cell recognizes antigen it synthesizes

Answer 1

antibodies

Question 2

antibodies attach to pathogens leading to

Answer 2

elimination

Question 3

variable heavy portion is encoded by

Answer 3

V D & J genes on chromosome 14

Question 4

two types of B cell activation

Answer 4

1. T cell dependent
2. T cell independent

Question 5

T cell dependent requires two signals

Answer 5

1. cross linking of receptors bound to antigen
2. T cell binding

Question 6

receptor crosslinking

Answer 6

pathogen binds multiple receptor and clusters them together

Question 7

B cells present antigen to T cells via

Answer 7

MCH class II

Question 8

CD40 (B cells) binding to CD40 (T cells) is required for

Answer 8

class switching

Question 9

B7 (B cells) binding to CD28 (T cells) is required for stimulation of

Answer 9

T cell cytokine production

Question 10

T cell independent activation is very important for

Answer 10

non protein antigens (polysaccharide & LPS)

Question 11

T cell independent produces mostly

Answer 11

IgM

Question 12

conjugated vaccines - polysaccharide antigen

Answer 12

no T cell stimulation
poor B cell memory
weak immune response

Question 13

conjugated vaccine - peptide antigen

Answer 13

B cells generate antibodies
antibody presented to T cell
T cells boost B cell response
strong immune protection

Question 14

examples of conjugated vaccines

Answer 14

H. influenza type B
neisseria meningitides
streptococcus pneumoniae

Question 15

other surface markers on B cells

Answer 15

CD19, CD20, CD21

Question 16

CD21 is the marker that allows infection by

Answer 16

EBV

Question 17

monomer antibodies

Answer 17

IgD, IgE, IgG

Question 18

dimer antibodies

Answer 18

IgA

Question 19

pentamer antibody

Answer 19

IgM

Question 20

antibody class determined by

Answer 20

Fc portion

Question 21

antibody functions

Answer 21

1. opsonization
2. neutralization
3. activate compliment

Question 22

key virulence factor of staph aureus

Answer 22

protein A

Question 23

protein A prevents

Answer 23

macrophage opsonization phagocytosis

Question 24

activated B cells initially produce

Answer 24

IgM

Question 25

triggers for class switching

Answer 25

IL-4, IL-5, CD40 ligand

Question 26

first antibody secreted during infection

Answer 26

IgM

Question 27

major antibody of secondary response

Answer 27

IgG

Question 28

only antibody that can cross placenta

Answer 28

IgG

Question 29

IgG is very important for

Answer 29

encapsulated bacteria

Question 30

IgA is found on

Answer 30

mucosal surfaces

Question 31

IgA is secreted into

Answer 31

milk to protect baby’s GI tract

Question 32

__ of IgA allows for secretion across mucosa

Answer 32

secretory component

Question 33

IgE bind to

Answer 33

mast cells & eosinophils

Question 34

IgE mediates

Answer 34

allergic reactions

Question 35

somatic hypermutation is important for

Answer 35

affinity maturation

Question 36

after activation B cells become

Answer 36

plasma cells
memory cells

Question 37

live attenuated vaccines provoke a __ response

Answer 37

cell mediated

Question 38

killed vaccines provoke a __ response

Answer 38

humoral

Question 39

example of live attenuated vaccine

Answer 39

MMR

Question 40

oral vaccines is mostly

Answer 40

IgA

Question 41

intramuscular vaccines is mostly

Answer 41

IgG

Question 42

passive immunization is the administration of

Answer 42

antibodies (mom to baby)