lymph nodes & spleen Flashcards

1
Q

primary lymphoid organs

A

sites of lymphocyte formation

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2
Q

secondary lymphoid organs

A

site where B and T cells proliferate

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3
Q

lymph fluid drains from

A

site of infection

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4
Q

in lymph fluid, __ are activated

A

dendritic cells

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5
Q

dendritic cells express

A

MHC I, MHC II, B7

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6
Q

dendritic cells present to

A

T cells

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7
Q

lymphoid follicles are found in

A

cortex of lymph node

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8
Q

lymphoid follicles are site of

A

B cells activation

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9
Q

follicular dendritic cells are

A

permanent cells of lymph nodes

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10
Q

__ are imp reservoir to HIV

A

follicular dendritic cells

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11
Q

primary lymphoid follicles are

A

inactive

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12
Q

secondary lymphoid follicles contain

A

germinal center

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13
Q

what happens are germinal center

A

B cell growth and class switching

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14
Q

2 key features of paracortex

A
  1. contain T cells activated by dendritic cells
  2. contain high endothelial venues
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15
Q

paracortex is underdeveloped in

A

T cell def disorders (DIGeorge syndrome)

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16
Q

medullary sinuses contain

A

macrophages (which lead to phagocytosis)

17
Q

medullary cords contain

A

plasma cells secreting antibodies

18
Q

spleen role

A

filters blood

19
Q

white pulp

A

exposure to B & T cells
exposure to macrophages

20
Q

red pulp

A

filters blood in sinusoids & removes old RBCs

21
Q

3 parts of white pulp

A
  1. marginal zone
  2. follicles
  3. periarteriolar lymphocyte sheath (PALs)
22
Q

marginal zone role

A

macrophages
remove debris
dendritic cells process antigens

23
Q

follicles contain

A

B cells

24
Q

PALs contain

A

T cells

25
Q

splenic dys leads to increased risk from

A

encapsulated organisms

26
Q

loss of marginal zone macrophages leads to

A

decreased phago & loss of opsonization

27
Q

predominant pathogen for sepsis

A

strep pneumo

28
Q

nuclear remnants normally cleared by spleen, if present signify a splenic dys

A

howell jolly bodies

29
Q

thrombocytosis is due to failure of

A

spleen to remove platelets