inflammation principles Flashcards
inflammation is a process for eliminating
pathogens & damaged tissue
5 cardinal signs of inflammation
- rubor
- calor
- tumor (swelling)
- dolor (pain)
- loss of function
histamine is
preformed & released quickly
histamine is released by
mast cells, basophils, & platelets
prostaglandin are synthesized via
arachidonic acid
prostaglandin are released by
mast cells & leukocytes
factor XII produces
bradykinin
bradykinin role
vasodilator & pain
bradykinin is degraded by
angiotensinogen converting enzyme (ACE)
ace inhibitors can raise bradykinin levels causing
angioedema
bradykinin is degraded by C1 also and a def in C1 can lead to
hereditary angioedema
vascular permeability is due to
contraction of endothelial cells creating gaps that occur in post capillary venules
oncotic pressure drive fluid into
tissue
exudate characteristics
high protein, concentrated
exudate seen in
inflammatory edema from high vascular permeability
transudate characteristics
low protein, diluted