acute & chronic inflammation Flashcards
acute inflammation is part of
innate immunity
3 hallmark features of acute inflammation
- increased blood flow
- increased vascular permeability
- emigration of neutrophils
phagocytes include
macrophages & neutrophils
guardians of innate immunity
macrophages
roles of macrophages
recognize cellular damage/foreign bodies & initiate acute inflammation response
macrophages recognized molecules that are forge in by
damage associated molecular patterns (DAMPS) or
pathogen associated molecular patterns (PAMPS)
key receptors on macrophages for damps & pamps
toll like receptors
key for recognition of cell damage
cytosolic protein complex
cytosolic protein complex is activated by
components of damaged cells
activated of cytosolic protein complex leads to production of
IL-1
vasoactive amines
histamine
serotonin
provide extra support to macrophages via phagocytosis
neutrophils
neutrophils exit blood via
post capillary venules
in acute infection __ dominates early
neutrophils
in acute infection __ dominates late
macrophages
pseudomonas infections what dominates
neutrophils for days
what dominates in hypersensitivity reactions
eosinophils
what occurs at same time in chronic inflammation
tissues destruction and repair
dom cell type in chronic inflam
macrophages
two types of macrophages
M1 & M2
M1 is activated by
classical pathway
M2 is activated by
alternative pathway
classical activation of M1
microbes activates macrophages which causes T cells to release IFN gamma which activates macrophage response
alternative M2 activation via
cytokines other than IFN gamma
M2 play a role in
tissue repair & inhibit classical activation
chronic inflammation outcomes
scarring
secondary amyloidosis
malignancy
neutrophils have
multi-lobed nuclei
