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acute & chronic inflammation Flashcards

1
Q

acute inflammation is part of

A

innate immunity

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2
Q

3 hallmark features of acute inflammation

A
  1. increased blood flow
  2. increased vascular permeability
  3. emigration of neutrophils
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3
Q

phagocytes include

A

macrophages & neutrophils

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4
Q

guardians of innate immunity

A

macrophages

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5
Q

roles of macrophages

A

recognize cellular damage/foreign bodies & initiate acute inflammation response

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6
Q

macrophages recognized molecules that are forge in by

A

damage associated molecular patterns (DAMPS) or
pathogen associated molecular patterns (PAMPS)

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7
Q

key receptors on macrophages for damps & pamps

A

toll like receptors

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8
Q

key for recognition of cell damage

A

cytosolic protein complex

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9
Q

cytosolic protein complex is activated by

A

components of damaged cells

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10
Q

activated of cytosolic protein complex leads to production of

A

IL-1

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11
Q

vasoactive amines

A

histamine
serotonin

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12
Q

provide extra support to macrophages via phagocytosis

A

neutrophils

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13
Q

neutrophils exit blood via

A

post capillary venules

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14
Q

in acute infection __ dominates early

A

neutrophils

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15
Q

in acute infection __ dominates late

A

macrophages

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16
Q

pseudomonas infections what dominates

A

neutrophils for days

17
Q

what dominates in hypersensitivity reactions

A

eosinophils

18
Q

what occurs at same time in chronic inflammation

A

tissues destruction and repair

19
Q

dom cell type in chronic inflam

A

macrophages

20
Q

two types of macrophages

A

M1 & M2

21
Q

M1 is activated by

A

classical pathway

22
Q

M2 is activated by

A

alternative pathway

23
Q

classical activation of M1

A

microbes activates macrophages which causes T cells to release IFN gamma which activates macrophage response

24
Q

alternative M2 activation via

A

cytokines other than IFN gamma

25
Q

M2 play a role in

A

tissue repair & inhibit classical activation

26
Q

chronic inflammation outcomes

A

scarring
secondary amyloidosis
malignancy

27
Q

neutrophils have

A

multi-lobed nuclei

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