platelet disorders

Question 1

glanzamann’s thrombasthenia genetics

Answer 1

autosomal recessive

Question 2

glanzamann’s thrombasthenia functional def of

Answer 2

GPIIb/IIIa

Question 3

glanzamann’s thrombasthenia blood smear

Answer 3

isolated platelets

Question 4

Bernard-soulier syndrome genetcis

Answer 4

autosomal recessive

Question 5

bernard soulier def of

Answer 5

GPIb

Question 6

Bernard soulier syndrome due to

Answer 6

platelets cannot bind vWF because def of GPIb

Question 7

findings in bernard

Answer 7

large platelets, thrombocytopenia

Question 8

giant platelets can be seen in association with

Answer 8

thrombocytopenia

Question 9

wiskott Aldrich syndrome genetics

Answer 9

x linked disorder of WAS gene

Question 10

triad of wiskott Aldrich

Answer 10

1. immune dys
2. decreased platelets
3. eczema

Question 11

idiopathic thromobytopenic purpura is disorder of

Answer 11

decreased platelet survival and consumption by splenic macrophages

Question 12

thrombotic thrombocytopenia purpura is disorder of

Answer 12

small vessel thrombus

Question 13

TTP is caused by

Answer 13

decreased activity of ADAMTS13 due to acquired antibodies

Question 14

microangipathic hemolytic anemia caused by

Answer 14

shearing of RBC when passing through narrow area

Question 15

sxs of TTP

Answer 15

fever, renal failure, petechiae, neurological sxs

Question 16

top treatment with plasma exchange

Answer 16

removes antibodies

Question 17

hemolytic uremic syndrome occurs in

Answer 17

children

Question 18

HUS is due to platelet rich thrombi in

Answer 18

small vessels

Question 19

HUS commonly follows

Answer 19

GI infection with e coli 0157:H7 shiga like toxin

Question 20

widespread activation of clotting cascade

Answer 20

DIC