systemic lupus erythematous Flashcards
key finding in SLE
anti-nuclear antibodies
antibody-antigen complexes circulate in plasma and elicit
type III hypersensitivity
antibody-antigen complexes activate
complement
low levels of __ in SLE
C3/C4
lupus specific antibodies
anti-double stranded DNA and anti-smith
lupus sensitive antibodies
anti nuclear antibodies
small nuclear ribonucleoprotein combine with RNA transcripts to form
spliceosome
spliceosome role
removes a portion of the RNA transcript
anti-smith antibody is directed toward
snRNP
SLE flare sxs
fever, WL, fatigue, lymphadenopathy
classic skin finding in lupus
malar rash
Raynaud phenomenon
white/blue fingertips
Raynaud phenomenon can lead to
fingertip ulcers
other sxs of SLE
oral ulcers
arthritis
serositis (inflammation of pleura/pericardium)
penias (anemia, thrombocytopenia)
lupus cerebritis sxs
cognitive dysfunction, stroke, seizures
lupus nephropathy
nephritic/nephrotic syndrome
mc SLE renal syndrome
diffuse proliferative glomerular nephritis
membranous glomerular nephritis
nephrotic syndrome
cardiac manifestations
Libman-sacks (marantic) endocarditis
__ antibodies occur in association with lupus
anti-phospholipid antibodies
three imp clinical consequences of anti-phospholipid antibodies
- increased risk of venous/arterial thrombosis
- increased PTT
- false positive syphilis
__ causes the false positive syphilis
anti-cardiolipin
lupus anticoagulant interferes with
PTT test
drug induced lupus classic drugs
INH
hydralazine
procainamide
key features of drug induced lupus
anti-histone antibodies
SLE treatment
steroids
avoid sunlight
neonatal lupus sxs
rash
congenital complete heart block
Libman-sacks endocarditis
nonbacterial inflammation of valves
classically affects both sides of mitral valve
