granulomatous inflammation Flashcards
granulomatous inflammation is subtype of
chronic inflammation
in granulomatous inflammation, macrophages transform to
epithelia cells
langerhans giant cells
granulomatous inflammation is what type of hypersensitivity
T cell mediated type IV
granulomas are epitheloid macrophages surrounded by
lymphocytes
some epitheloid macrophages fuse to form
giant cells
__ accumulate in granulomatous inflammation
Th1 CD4+ T cells
Th1 CD4+ T cells secrete
IL-2 and IFN gamme
chronic granulomatous disease is due to
loss of function of NADPH oxidase
loss of function of NADPH oxidase causes
phago cant make hydrogen peroxide
in chronic granulomatous disease patients are more susceptible to
recurrent infections with catalase pos bacteria
five organisms that cause CGD
staph aureus
pseudomonas
serratia
nocardia
aspergillus
caseating granuloma due to
necrosis
caseating granuloma classically seen in
tuberculosis
__ maintains granulomatous inflammation
TNF alpha
infliximab
anti-TNF antibody
