other anemias

Question 1

EPO is synthesized in the

Answer 1

kidney

Question 2

EPO is released in response to

Answer 2

hypoxia

Question 3

EPO is decreased in

Answer 3

renal failure

Question 4

aplastic anemia is loss of

Answer 4

hematopoietic precursors in bone marrow

Question 5

aplastic anemia results in

Answer 5

pancytopenia

Question 6

in bone marrow failure, the bone marrow cannot

Answer 6

produce cells

Question 7

hallmarks of aplastic anemia

Answer 7

1. pancytopenia
2. acellular bone marrow

Question 8

sxs of aplastic anemia

Answer 8

1. pancytopenia
2. anemia
3. thrombocytopenia (bleeding)
4. leukopenia

Question 9

with idiopathic aplastic anemia there is strong evidence for

Answer 9

immune mediated mechanism (T cell mediated destruction of stem cells)

Question 10

idiopathic anemia due to T cell destruction can be treated with

Answer 10

antithymocyte globulin
cyclosporine

Question 11

other causes of aplastic anemia

Answer 11

radiation
acute viral hepatitis
parvovirus B19
drugs
benzene

Question 12

fanconi anemia is a

Answer 12

inherited aplastic anemia

Question 13

fanconi anemia genetics

Answer 13

autosomal recessive or x linked

Question 14

more than half of patients with fanconi anemia have

Answer 14

physical deformities

Question 15

physical deformities of fanconi syndrome

Answer 15

1. short statue
2. cafe au lait spots
3. malformed thumbs
4. heart, renal, eye abnormalities

Question 16

fanconi anemia genetic abnormalities typically involve

Answer 16

dna repair enzymes

Question 17

fanconi syndrome caused increased risk of

Answer 17

malignancies

Question 18

pure red cell aplasia is

Answer 18

absence of erythroid precursors

Question 19

pure red cell aplasia has marked reduction in

Answer 19

reticulocytes

Question 20

key association with pure red cell aplasia

Answer 20

thymoma

Question 21

macrocytic anemias are characterized by

Answer 21

abnormal DNA synthesis

Question 22

in megaloblastic anemias red blood cell precursors grow but

Answer 22

cannot divide

Question 23

megaloblastic anemia results from

Answer 23

abnormal DNA synthesis

Question 24

what can be seen on red blood cell smear of megaloblastic anemia

Answer 24

hypersegmented neutrophils

Question 25

causes of megaloblastic anemia

Answer 25

folate deficiency and B12

Question 26

macrocytic anemias without impaired DNA synthesis can be due to

Answer 26

liver disease or alcoholism