extrinsic hemolysis

Question 1

autoimmune hemolytic anemia due to

Answer 1

RBC destruction from autoantibodies

Question 2

warm AIHA - antibodies bind at

Answer 2

body temp

Question 3

antibodies seen in warm AIHA

Answer 3

IgG

Question 4

warm AIHA sxs

Answer 4

anemia, extravascular hemolysis

Question 5

diagnostic finding in AIHA

Answer 5

spherocytes (smaller than RBC, spherical with no central pallor)

Question 6

direct antiglobulin test tests for

Answer 6

red blood cell antibodies

Question 7

postive DAT test means

Answer 7

RBC covered in IgG

Question 8

indirect antiglobulin test tests for

Answer 8

antibodies in serum

Question 9

methydopa used for

Answer 9

HTN in pregnancy

Question 10

methyldopa is associated with

Answer 10

warm AIHA by triggers RBC antibodies

Question 11

penicillin binds to

Answer 11

surface of RBC and elicits immune response causing AIHA

Question 12

treatment of warm AIHA

Answer 12

glucocorticoids, splenectomy

Question 13

cold AIHA binds at __ and occurs in __

Answer 13

<30 celcius occurs in limbs

Question 14

cold AIHA is caused by

Answer 14

IgM antibodies that agglutinate RBCs

Question 15

in cold AIHA DAT will be positive for

Answer 15

C3

Question 16

cold AIHA usually causes

Answer 16

extravascular hemolysis

Question 17

cold AIHA often occurs secondary to

Answer 17

infection (mycoplasma, EBV)

Question 18

microangiopathic hemolytic anemia due to

Answer 18

shearing of RBCs in small blood vessels

Question 19

blood smear in MAHA

Answer 19

schistocytes

Question 20

MAHA is associated with

Answer 20

malignant hypertension

Question 21

mechanical hemolysis

Answer 21

shear forces destroy RBC in large vessels

Question 22

mechanical hemolysis is seen in

Answer 22

aortic stenosis, mechanical heart valves