rheumatoid arthritis Flashcards

1
Q

synovium secretes

A

hyaluronic acid

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2
Q

RA is antibody mediated

A

type III hypersensitivity

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3
Q

synovium thickens into

A

pannus

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4
Q

synovial hypertrophy erodes into

A

cartilage & bone

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5
Q

__ joint inflammation

A

symmetric

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6
Q

classic sxs

A

morning stiffness that improves with use

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7
Q

RA classically affects

A

MCP & PIP

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8
Q

__ deviation seen in RA

A

ulnar

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9
Q

__ deformity common

A

swan neck

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10
Q

bakers cysts (popliteal cyst)

A

synovium-lined sac at back of knee

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11
Q

if bakers cyst ruptures sxs similar to

A

DVT

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12
Q

RA serositis

A

pleuritis
pericarditis

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13
Q

___ almost always occur in patient RF+

A

subcutaneous nodules

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14
Q

eye findings in RA

A

episcleritis
scleritis
uveitis

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15
Q

sjogrens syndrome

A

salivary & lacrimal glands
dry eyes/mouth

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16
Q

__ is accelerated by RA

A

osteoporosis

17
Q

specific marker of RA

A

citrullinated peptides

18
Q

nonstandard amino acid that can be incorporated into proteins via post translational modification

A

citrulline

19
Q

elevated __ & __ in RA

A

CRP & ESR

20
Q

RA has strong association with

A

HLA-DR4

21
Q

long term complications of RA

A

increased risk of coronary artery disease
amyloidosis

22
Q

felty syndrome is syndrome of

A

splenomegaly
neutropenia

23
Q

sulfasalazine inhibits

A

TNF alpha from binding to receptor

24
Q

leflunomide inhibits

A

dihydroorotate dehydrogenase which inhibits pyrimidine synthesis (immunosuppression)