rheumatoid arthritis Flashcards
synovium secretes
hyaluronic acid
RA is antibody mediated
type III hypersensitivity
synovium thickens into
pannus
synovial hypertrophy erodes into
cartilage & bone
__ joint inflammation
symmetric
classic sxs
morning stiffness that improves with use
RA classically affects
MCP & PIP
__ deviation seen in RA
ulnar
__ deformity common
swan neck
bakers cysts (popliteal cyst)
synovium-lined sac at back of knee
if bakers cyst ruptures sxs similar to
DVT
RA serositis
pleuritis
pericarditis
___ almost always occur in patient RF+
subcutaneous nodules
eye findings in RA
episcleritis
scleritis
uveitis
sjogrens syndrome
salivary & lacrimal glands
dry eyes/mouth
__ is accelerated by RA
osteoporosis
specific marker of RA
citrullinated peptides
nonstandard amino acid that can be incorporated into proteins via post translational modification
citrulline
elevated __ & __ in RA
CRP & ESR
RA has strong association with
HLA-DR4
long term complications of RA
increased risk of coronary artery disease
amyloidosis
felty syndrome is syndrome of
splenomegaly
neutropenia
sulfasalazine inhibits
TNF alpha from binding to receptor
leflunomide inhibits
dihydroorotate dehydrogenase which inhibits pyrimidine synthesis (immunosuppression)
