coagulopathies Flashcards
bleeding time is a test of
platelet function
normal activated partial thromboplastin time
30s
normal prothrombin time
10s
thrombin time
add thrombin to sample time to form clot
abnormal platelets sxs
mucosal bleeding, skin bleeding, petechiae
abnormal coagulation factors sxs
joint bleeding, deep tissue bleeding
hemophilias genetics
x linked recessive diseases
hemophilia A
def of factor VIII
hemophilia B
def of factor IX
hemophilias present with
spontaneous or easy bruising and recurrent joint bleeds
screening for hemophilia
PTT will be prolonged
PT, bleeding time, and platelet count will all be normal in
hemophilia
desmopressin can be used to treat
mild hemophilia A
desmopressin role increases
vWF and factor VIII levels and releases VIII from weibel-palade bodies
desmopressin key side effects
flushing and HA
aminocaproic acid use
antifibrinolytic drug
aminocaproic acid moa
plasminogen activation to plasmin (less breakdown of clots)
cryoprecipitate contains
factor VIII and fibrinogen
cryoprecipitate is often used as source of
fibrinogen
mixing study will differentiate
coagulation factor inhibitors from hemophilia A
vit k def results in
bleeding
key lab findings in vit k def
elevated PT/INR
large volume blood transfusion cause
dilution of clotting factors
packed RBCs are devoid of
plasma/platelets
in liver disease loss of
clotting factors
